Evidence map›Paper›PMID 35860588›Full record

ArticleFrontiers in oncology2022

Tumor-Associated Macrophages Correlate With Prognosis in Medulloblastoma.

Jin Zhang, Xia Yuan, Yuan Wang, Jingjing Liu, Zhigang Li, Shuting Li, Yan Liu, Xiaojun Gong, Yanling Sun, Wanshui Wu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Jin ZhangDepartment of Pediatrics, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Xia YuanState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Yuan WangDepartment of Pediatrics, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Jingjing LiuDepartment of Pediatrics, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Zhigang LiHematologic Disease Laboratory, Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Disease in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Shuting LiDepartment of Pediatrics, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Yan LiuDepartment of Pediatrics, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Xiaojun GongDepartment of Pediatrics, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Yanling SunDepartment of Pediatrics, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Wanshui WuDepartment of Pediatrics, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Liming SunDepartment of Pediatrics, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Shuxu DuDepartment of Pediatrics, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Tianyou WangHematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Disease in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Capital Medical University · CNBeijing Shijitan Hospital · CNBeijing Children’s Hospital · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Macrophage polarization plays an essential role in the tumor microenvironment of brain tumors. However, the role of tumor-associated macrophages (TAMs) in medulloblastoma still remains controversial. Thus, we investigated the distribution of macrophages in medulloblastoma tissues and analyzed the association of TAM recruitment and medulloblastoma patients' outcomes. Methods: We obtained a total of 71 paraffin sections from patients with medulloblastoma, and detected the activated phenotype (M1/M2) by monoclonal antibodies for CD68, HLA-DR and CD163 with multiple fluorescence immunohistochemistry method. The number of polarized macrophages was quantified using the InForm software. Outcomes were analyzed according to clinical data and quantified macrophage data. Results: The study revealed that TAMs were significantly higher in sonic hedgehog (SHH) medulloblastoma than in other subgroups, and M1 macrophages in metastatic group were significantly higher than those in non-metastatic group. A Kaplan-Meier survival analysis and multivariate Cox regression model showed the correlation of high percentage of total macrophages ( Conclusion: High percentage of total macrophages and M1 macrophages are correlated with good outcome of medulloblastoma patients. TAMs might be a target of therapy.

Indexed as

immunotherapymacrophagemedulloblastomaphenotypeprognosis

Identifiers

PMID35860588
PMCPMC9289152
OpenAlexW4283794734

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.