Evidence map›Paper›PMID 35860501›Full record

ArticleFrontiers in molecular neuroscience2022

Highly Parallelized, Multicolor Optogenetic Recordings of Cellular Activity for Therapeutic Discovery Applications in Ion Channels and Disease-Associated Excitable Cells.

Gabriel B Borja, Hongkang Zhang, Benjamin N Harwood, Jane Jacques, Jennifer Grooms, Romina O Chantre, Dawei Zhang, Adam Barnett, Christopher A Werley, Yang Lu and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Gabriel B BorjaQ-State Biosciences, Cambridge, MA, United States.
Hongkang ZhangQ-State Biosciences, Cambridge, MA, United States.
Benjamin N HarwoodQ-State Biosciences, Cambridge, MA, United States.
Jane JacquesQ-State Biosciences, Cambridge, MA, United States.
Jennifer GroomsQ-State Biosciences, Cambridge, MA, United States.
Romina O ChantreQ-State Biosciences, Cambridge, MA, United States.
Dawei ZhangQ-State Biosciences, Cambridge, MA, United States.
Adam BarnettQ-State Biosciences, Cambridge, MA, United States.
Christopher A WerleyQ-State Biosciences, Cambridge, MA, United States.
Yang LuQ-State Biosciences, Cambridge, MA, United States.
Steven F NagleQ-State Biosciences, Cambridge, MA, United States.
Owen B McManusQ-State Biosciences, Cambridge, MA, United States.
Graham T DempseyQ-State Biosciences, Cambridge, MA, United States.
Q-State Biosciences (United States) · US

Funding

An all-optical electrophysiology platform for the discovery of pain therapeuticsR44NS107041 · NINDS · Q-STATE BIOSCIENCES, INC. · PI MCMANUS, OWEN B. · 2018 to 2020
$2.0M
High-throughput, all-optical assay in human cardiomyoctes for clinically relevant prediction of drug induced cardiotoxity.R44HL126314 · NHLBI · Q-STATE BIOSCIENCES, INC. · PI DEMPSEY, GRAHAM THOMAS, MARGULIES, DAVID · 2016 to 2017
$972k
NHLBI NIH HHS R44 HL126314NINDS NIH HHS R44 NS107041
6 · The paper itself

Abstract

Optogenetic assays provide a flexible, scalable, and information rich approach to probe compound effects for ion channel drug targets in both heterologous expression systems and associated disease relevant cell types. Despite the potential utility and growing adoption of optogenetics, there remains a critical need for compatible platform technologies with the speed, sensitivity, and throughput to enable their application to broader drug screening applications. To address this challenge, we developed the Swarm

Indexed as

drug discoveryhigh-throughput screeninghuman iPSC modelsion channelsoptogeneticsoptopatchpainvoltage-gated sodium channels

Identifiers

PMID35860501
PMCPMC9289666
OpenAlexW4283819714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.