Evidence map›Paper›PMID 35860385›Full record

ArticleMolecular therapy. Nucleic acids2022

Developing antisense oligonucleotides for a

Luis A Williams, David J Gerber, Amy Elder, Wei Chou Tseng, Valeriya Baru, Nathaniel Delaney-Busch, Christina Ambrosi, Gauri Mahimkar, Vaibhav Joshi, Himali Shah and 21 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. The lncRNAGenes & development · 2024
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 7 institutions in 3 countries.

Luis A WilliamsQ-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
David J GerberQ-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Amy ElderQ-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Wei Chou TsengQ-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Valeriya BaruQ-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Nathaniel Delaney-BuschQ-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Christina AmbrosiQ-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Gauri MahimkarQ-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Vaibhav JoshiQ-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Himali ShahQ-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Karthiayani HarikrishnanQ-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Hansini UpadhyayQ-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Sakthi H RajendranQ-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Aishwarya DhandapaniQ-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Joshua MeierQ-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Steven J RyanQ-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Caitlin LewarchQ-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Lauren BlackCharles River Laboratories, Montreal, QC, Canada.
Julie DouvilleCharles River Laboratories, Montreal, QC, Canada.
Stefania CinquinoCharles River Laboratories, Montreal, QC, Canada.
Helen LegakisCharles River Laboratories, Montreal, QC, Canada.
Karsten NalbachMunich Cluster for Systems Neurology, Ludwig-Maximilians-Universität München, Germany.
Christian BehrendsMunich Cluster for Systems Neurology, Ludwig-Maximilians-Universität München, Germany.
Ai SatoDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Lorenzo GalluzziDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Timothy W YuBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Duncan BrownQ-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Sudhir AgrawalUniversity of Massachusetts Medical School, Department of Medicine, Worcester, MA 01655, USA.
David MarguliesQ-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Alan KopinTufts University School of Medicine, Boston, MA, USA.
Graham T DempseyQ-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.
Q-State Biosciences (United States) · USCanadian Nuclear Laboratories · CACornell University · USMunich Cluster for Systems Neurology · DEBoston Children's Hospital · USTufts University · USUniversity of Massachusetts Chan Medical School · US

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
NICHD NIH HHS P50 HD105351
6 · The paper itself

Abstract

Mutations in the

Indexed as

antisense oligonucleotideCNS disorderHSAN9human induced pluripotent stem cellsOligonucleotides: Therapies and ApplicationsSPG49TECPR2

Identifiers

PMID35860385
PMCPMC9287140
OpenAlexW4283375432

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.