Revisiting Fluoride in the Twenty-First Century: Safety and Efficacy Considerations.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

17 citing papers in PubMed, 34 citations in OpenAlex.

1. [Efficacy and cost analysis of two fluoride varnishes in community-based interventions for early childhood caries].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026
   Trial
2. Navigating fluoride hesitancy: mapping the evidence base for fluoride-free toothpaste alternatives.European journal of pediatrics · 2026
   Review
3. The Journey of Oral Hygiene: The Past, the Present, the Future.Journal of periodontal research · 2026
   Article
4. Oral hygiene agents at work: effects onFrontiers in cellular and infection microbiology · 2026
   Review
5. Evaluation of Factors Affecting Fluoride Release from Dental Sealants: A Systematic Review.Materials (Basel, Switzerland) · 2025
   Review
6. Risk factors of early childhood caries among preschool children in Shanghai, China: a longitudinal study.Frontiers in oral health · 2025
   Article
7. Hydroxyapatite in Oral Care Products: In vitro Effects on Erosion/Abrasion and Analysis of Formulation Components.Caries research · 2025
   Article
8. Fluoride-induced Neurodevelopmental Toxicity- AMPK as a Possible Target.CNS & neurological disorders drug targets · 2025
   Review
9. Topical fluoride and regulation of salivary pH in Peruvian Altiplano schoolchildren: a comparative longitudinal study.Frontiers in oral health · 2025
   Article
10. Comparative Perceptions of Fluoride Toxicity in Oral Hygiene Products: Insights from the General Population and Healthcare Professionals.Clinics and practice · 2024
    Article
11. Silver Compounds for Caries Management.International dental journal · 2024
    Review
12. Physicochemical properties, biological chemistry and mechanisms of action of caries-arresting diammine-silver(I) fluoride and silver(I)-fluoride solutions for clinical use: a critical review.Frontiers in oral health · 2024
    Review
13. A Short Review of the Toxicity of Dentifrices-Zebrafish Model as a Useful Tool in Ecotoxicological Studies.International journal of molecular sciences · 2023
    Review
14. Hydrogel-Encapsulated Biofilm Inhibitors Abrogate the Cariogenic Activity ofJournal of medicinal chemistry · 2023
    Article
15. Fluorescence-Based Portable Assays for Detection of Biological and Chemical Analytes.Sensors (Basel, Switzerland) · 2023
    Review
16. Attitude, Practice, and Knowledge Regarding Fluoridated Toothpaste, Brushing, and Rinse Usage Among Residents of Jeddah City in Saudi Arabia.Patient preference and adherence · 2023
    Article
17. The role of plant growth promoting rhizobacteria in strengthening plant resistance to fluoride toxicity: a review.Frontiers in microbiology · 2023
    Review

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

3 authors at 2 institutions in 2 countries.

Funding

No grant is acknowledged in the PubMed record.

Abstract

Indexed as