Evidence map›Paper›PMID 35860238›Full record

ArticleFrontiers in immunology2022

Alterations of NK Cell Phenotype During Pregnancy in Multiple Sclerosis.

Anne Wisgalla, Caren Ramien, Mathias Streitz, Stephan Schlickeiser, Andreea-Roxana Lupu, Anke Diemert, Eva Tolosa, Petra C Arck, Judith Bellmann-Strobl, Nadja Siebert and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Innate Immunity in Autoimmune Thyroid Disease during Pregnancy.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Anne WisgallaMedizinische Klinik m.S. Psychosomatik, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
Caren RamienInstitut für Neuroimmunologie und Multiple Sklerose (INIMS), Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Mathias StreitzInstitut für Medizinische Immunologie, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany.
Stephan SchlickeiserInstitut für Medizinische Immunologie, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany.
Andreea-Roxana LupuCantacuzino National Military Medical Institute for Research and Development, Bucharest, Romania.
Anke DiemertKlinik für Geburtshilfe und Pränatalmedizin, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Eva TolosaInstitut für Immunologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Petra C ArckKlinik für Geburtshilfe und Pränatalmedizin, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Judith Bellmann-StroblExperimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) and Charité-Universitätsmedizin Berlin, Berlin, Germany.
Nadja SiebertExperimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) and Charité-Universitätsmedizin Berlin, Berlin, Germany.
Christoph HeesenInstitut für Neuroimmunologie und Multiple Sklerose (INIMS), Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Friedemann PaulExperimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) and Charité-Universitätsmedizin Berlin, Berlin, Germany.
Manuel A FrieseInstitut für Neuroimmunologie und Multiple Sklerose (INIMS), Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Carmen Infante-DuarteExperimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) and Charité-Universitätsmedizin Berlin, Berlin, Germany.
Stefan M GoldMedizinische Klinik m.S. Psychosomatik, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
Charité - Universitätsmedizin Berlin · DEMax Delbrück Center · DEUniversität Hamburg · DEUniversity Medical Center Hamburg-Eppendorf · DEFriedrich-Loeffler-Institut · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In multiple sclerosis (MS), relapse rate is decreased by 70-80% in the third trimester of pregnancy. However, the underlying mechanisms driving this effect are poorly understood. Evidence suggests that CD56

Indexed as

Multiple SclerosisCD56 AntigenCohort StudiesFemaleHumansKiller Cells, NaturalPhenotypePregnancyCD56 AntigenFlowSOM clusteringimmune profilingimmune tolerancemultiple sclerosisnatural killer cellspregnancy

Identifiers

PMID35860238
PMCPMC9289470
OpenAlexW4283790121

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.