ArticleColloids and surfaces. A, Physicochemical and engineering aspects2022
Iron-containing metal-organic framework thin film as a drug delivery system.
Article in Colloids and surfaces. A, Physicochemical and engineering aspects, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Recovery of ferulic acid from nixtamalization wastewater by adsorption on MIL-88D(Fe)-MOF.RSC advances · 2026Article
- A Green Process for Effective Direct Recycling and Reuse of Graphite from End-of-Life Li-Ion Batteries Black Mass.ChemSusChem · 2025Article
- Metal-Organic Framework Thin Films as Drug Delivery Systems.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Chemical Bonding and Crystal Structure Schemes in Atomic/Molecular Layer Deposited Fe-Terephthalate Thin Films.Chemistry of materials : a publication of the American Chemical Society · 2024Article
- Phenol as a Tethering Group to Gold Surfaces: Stark Response and Comparison to Benzenethiol.The journal of physical chemistry letters · 2023Article
- Application and Development Prospect of Nanoscale Iron Based Metal-Organic Frameworks in Biomedicine.International journal of nanomedicine · 2023Review
- pH-Responsive Metal-Organic Framework Thin Film for Drug Delivery.Langmuir : the ACS journal of surfaces and colloids · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Selective bulk metal-organic frameworks (MOFs) have exhibited great potential in biomedical applications. However, topical treatments and drug elution coatings will require uniform films as drug delivery systems. This work studies the use of surface supportive MOF thin films for drug loading and releasing. More specifically, we focus on an iron-containing MOF, MIL-88B(Fe), on a COOH-terminated self-assembled monolayer (SAM) modified Au surface for encapsulating ibuprofen as a model drug. A combined experimental and computational approach was employed to study the fabrication of MIL-88B(Fe) film on functionalized Au surfaces. We used several surface characterization techniques, including infrared spectroscopy and scanning electron microscopy, to confirm the chemical composition and morphological changes of the surface after each modification step. The resulting MIL-88B(Fe) thin film was found capable of loading 8.7 wt% of ibuprofen using quartz crystal microbalance analysis. Moreover, we applied cluster simulations to study the binding mechanisms of MIL-88B(Fe) and its interactions with ibuprofen based on the density functional theory (DFT). The unsaturated Fe site was confirmed kinetically more favorable to bind to the COOH-end group on the SAM. Hydrogen bonding and π-CH interactions between ibuprofen and MIL-88B(Fe) promote ibuprofen being retained inside of the cages of MIL-88B(Fe).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.