ArticleAnnals of medicine and surgery (2012)2022
Disseminated intravascular coagulation initial score as a predictor of mortality in children with dengue shock syndrome: A retrospective cohort study.
Article in Annals of medicine and surgery (2012), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Review
- In-Hospital Mortality in Mechanically Ventilated Children With Severe Dengue Fever: Explanatory Factors in a Single-Center Retrospective Cohort From Vietnam, 2013-2022.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025Article
- Immuno-Haematologic Aspects of Dengue Infection: Biologic Insights and Clinical Implications.Viruses · 2024Review
- Outcomes of Overt and Non-overt Disseminated Intravascular Coagulation Using the ISTH DIC Scoring System in Children: A Single-Center Study.Mediterranean journal of hematology and infectious diseases · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The mortality of dengue shock syndrome (DSS) in children is still high at 12-44%. Assessment of DIC initial score using the International Society on Thrombosis and Haemostasis scoring system can help diagnosing and treating DIC, while also predicting mortality in pediatric patients with DSS. Methods: We retrospectively collected data of children with DSS at Dr. Sardjito Hospital between January 2017 and June 2021 with inclusion criteria such as age 1 month to 18 years and laboratory parameters taken within first 24 h after DSS workup. Results: Results showed a sample population consisting of 20 male subjects (58.8%), 24 aged >5 years (76.0%), 21 with good nutritional status (61.8%), and median length of stay 5 days (3-7), with saturation of 98% (97-99) and median pediatric Glasgow coma scale level of consciousness of 13. The laboratory profile showed median levels of hematocrit at 40.9% (32.9-44.9), thrombocytes at 20,500/L (14,000-32,000), prothrombin time of 17.8 s (14.9-25.3), fibrinogen at 123 mg/dL (106-184) and D-dimer at 832.5 ng/mL (362-1119). A DIC initial score of ≥5 25 (73.5%) resulted with a mortality of 9 children (36.0%) with a 92% survival rate in the first 6 h. The first 6-h survival according to each DIC score parameter showed 93.8%, 100%, 85.7%, and 94.1% of thrombocytes ≤50,000 μ/L, fibrinogen <100 mg/dL, D-dimer >1000 ng/mL, and prothrombin time >6 s, respectively. Conclusion: A DIC initial score ≥5 can be used as a mortality predictor in the first 6 h after DSS diagnosis.
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