Evidence map›Paper›PMID 35859951›Full record

ReviewCureus2022

Application of Collagen-Based Scaffolds for the Treatment of Spinal Cord Injuries in Animal Models: A Literature Update.

Dimitrios Zachariou, Dimitrios Stergios Evangelopoulos, Meletis Rozis, Eftychios Papagrigorakis, Athanasios Galanis, Michail Vavourakis, Spyros G Pneumaticos, John Vlamis

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Dimitrios Zachariou3rd Orthopaedic Department, National and Kapodestrian University of Athens, KAT General Hospital, Athens, GRC.
Dimitrios Stergios Evangelopoulos3rd Orthopaedic Department, National and Kapodestrian University of Athens, KAT General Hospital, Athens, GRC.
Meletis Rozis3rd Orthopaedic Department, National and Kapodestrian University of Athens, KAT General Hospital, Athens, GRC.
Eftychios Papagrigorakis3rd Orthopaedic Department, National and Kapodestrian University of Athens, KAT General Hospital, Athens, GRC.
Athanasios Galanis3rd Orthopaedic Department, National and Kapodestrian University of Athens, KAT General Hospital, Athens, GRC.
Michail Vavourakis3rd Orthopaedic Department, National and Kapodestrian University of Athens, KAT General Hospital, Athens, GRC.
Spyros G Pneumaticos3rd Orthopaedic Department, National and Kapodestrian University of Athens, KAT General Hospital, Athens, GRC.
John Vlamis3rd Orthopaedic Department, National and Kapodestrian University of Athens, KAT General Hospital, Athens, GRC.
National and Kapodistrian University of Athens · GRGeneral Hospital of Attica · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SCI is regarded as one of the most devastating central nervous system (CNS) injuries, exhibiting an alarmingly rising incidence rate, indirectly connected with the expansion of the global economy. The consequences of SCI are multidimensional: SCI injuries may result in permanent voluntary motor dysfunction and loss of sensation while incurring heavy economic and psychological burdens as part of the treatment. Thus, it is crucial to develop effective and suitable SCI treatment strategies. Collagen-based scaffold application is one of the most promising methods of SCI treatment. This review compiles newer bibliographical data regarding the application of collagen scaffolds for the treatment of Spinal cord injury (SCI) in animal models. Recently, several relevant studies have been carried out using carefully selected animals with similar pathophysiology to humans. In mouse, rat and canine models that have undergone transection or hemisection, the stump connection, the transplanted cell differentiation, and the elimination of glial scar are promising. Also, encouraging results have been found regarding the increased neuronal growth, the decreased collagen deposition, the behavioral recovery, the improved electrophysiology, and the enhanced axonal regeneration.

Indexed as

animal modelcollagen-based scaffoldscaffoldspinal cord injury (sci)spinal cord regenerationtissue engineering & regenerative medicine

Identifiers

PMID35859951
PMCPMC9288156
OpenAlexW4283021487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.