Evidence map›Paper›PMID 35859732›Full record

ArticleOncoimmunology2022

Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis.

Ángela Bella, Leire Arrizabalaga, Claudia Augusta Di Trani, Assunta Cirella, Myriam Fernandez-Sendin, Celia Gomar, Joan Salvador Russo-Cabrera, Inmaculada Rodríguez, José González-Gomariz, Maite Alvarez and 7 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 3 countries.

Ángela BellaProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
Leire ArrizabalagaProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
Claudia Augusta Di TraniProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
Assunta CirellaProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
Myriam Fernandez-SendinProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
Celia GomarProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
Joan Salvador Russo-CabreraProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
Inmaculada RodríguezProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
José González-GomarizProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
Maite AlvarezProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
Álvaro TeijeiraProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
José Medina-EcheverzImmunology Research, Bavarian Nordic GmbH, Planegg, Germany.
Maria HinterbergerImmunology Research, Bavarian Nordic GmbH, Planegg, Germany.
Hubertus HochreinImmunology Research, Bavarian Nordic GmbH, Planegg, Germany.
Ignacio MeleroProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
Pedro BerraondoProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.ORCID 0000-0001-7410-1865
Fernando ArandaProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.ORCID 0000-0002-9364-474X
Navarre Institute of Health Research · ESBavarian Nordic (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recombinant-modified vaccinia virus Ankara (rMVA) is known to elicit potent antitumor immune responses in preclinical models due to its inherent ability to activate the innate immune system and the activation of adaptive responses mediated by the expression of tumor antigens and costimulus-providing molecules, such as CD40L and CD137L. Here, we evaluated different rMVA vectors in preclinical peritoneal carcinomatosis models (ID8.OVA-

Indexed as

Peritoneal NeoplasmsVaccinia4-1BB LigandAnimalsCD40 LigandImmunityMiceVaccinia virus4-1BB LigandCD40 LigandTnfsf9 protein, mousecancer immunotherapyCD137LCD40LCD8 immune responsePeritoneal carcinomatosis

Identifiers

PMID35859732
PMCPMC9291657
OpenAlexW4285393968

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.