Evidence map›Paper›PMID 35859701›Full record

ArticleAmerican journal of ophthalmology case reports2022

Raloxifene induced keratopathy: A case report.

Ji Min Park, Kyeong Do Jeong, Min-Ji Kang, Jee Hye Lee, Jae Suk Kim, Je Hyung Hwang

Open access · goldAbstract readCase Reports
In one paragraph

Article in American journal of ophthalmology case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. A case of corneal opacity caused by atovaquone administration.American journal of ophthalmology case reports · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ji Min ParkDepartment of Ophthalmology, Sanggye Paik Hospital, Inje University College of Medicine, 1342, Dongil-ro, Nowon-gu, Seoul, 01757, Republic of Korea.
Kyeong Do JeongEyelove Eye Clinic, 16, Apgujeong-ro 30-gil, Gangnam-gu, Seoul, 06022, Republic of Korea.
Min-Ji KangDepartment of Ophthalmology, Sanggye Paik Hospital, Inje University College of Medicine, 1342, Dongil-ro, Nowon-gu, Seoul, 01757, Republic of Korea.
Jee Hye LeeDepartment of Ophthalmology, Sanggye Paik Hospital, Inje University College of Medicine, 1342, Dongil-ro, Nowon-gu, Seoul, 01757, Republic of Korea.
Jae Suk KimDepartment of Ophthalmology, Sanggye Paik Hospital, Inje University College of Medicine, 1342, Dongil-ro, Nowon-gu, Seoul, 01757, Republic of Korea.
Je Hyung HwangDepartment of Ophthalmology, Sanggye Paik Hospital, Inje University College of Medicine, 1342, Dongil-ro, Nowon-gu, Seoul, 01757, Republic of Korea.
Inje University Sanggye Paik Hospital · KROnnuri Smile Eye Clinic · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: We report a case of corneal verticillata in a patient who had been taking raloxifene for a prolonged period. To our knowledge, this is the first case report of an ocular side effect of raloxifene. Observations: A 69-year-old female patient presented to our clinic for her routine eye check-up. On slit-lamp examination, whorl-like subepithelial deposits were observed in the bilateral corneas. She was diagnosed with corneal verticillata (vortex keratopathy) caused by raloxifene. A follow-up evaluation was conducted after discontinuation of the drug; however, the corneal opacity did not improve. Conclusions and importance: Patients with corneal verticillata should be asked regarding any intake of raloxifene for osteoporosis, as it may cause corneal verticillata.

Indexed as

Drug-induced keratopathyKeratopathyRaloxifeneSelective estrogen receptor modulator

Identifiers

PMID35859701
PMCPMC9289629
OpenAlexW4285384497

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.