ArticleFrontiers in psychiatry2022
Functional Brain Networks in Preschool Children With Autism Spectrum Disorders.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Alteration of individual morphological brain networks in preschool children with autism spectrum disorder.Brain imaging and behavior · 2026Article
- A null findings study: graph theoretical analysis of the fetal functional connectome shows no relationships with future autistic traits.Neuroimage. Reports · 2026Article
- Common and distinct changes of regional resting-state brain activity between high- and low-functioning autism spectrum disorder.BMC psychiatry · 2026Article
- The hidden costs of screen time: altered brain network efficiency in children with autism spectrum disorder.BMC psychiatry · 2026Article
- Reduced local functional connectivity correlates with atypical performances in children with autism spectrum disorder.Brain imaging and behavior · 2025Article
- Perirhinal cortex abnormalities impair hippocampal plasticity and learning inScience advances · 2025Article
- rTMS-induced neuroimaging changes measured with structural and functional MRI in autism.Frontiers in neuroscience · 2025Article
- Abnormalities in rich-club connections are associated with an exacerbation of genetic susceptibility to schizophrenia.BMC psychiatry · 2024Article
- Spatial-Temporal Characteristics of Brain Activity in Autism Spectrum Disorder Based on Hidden Markov Model and Dynamic Graph Theory: A Resting-State fMRI Study.Brain sciences · 2024Article
- Secondary analysis: Graph analysis of brain connectivity network in autism spectrum disorder.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024Article
- The Influence of Sleep Disorders on Neurobiological Structures and Cognitive Processes in Pediatric Population with ASD and Epilepsy: A Systematic Review.European journal of investigation in health, psychology and education · 2023Review
- Molecular Abnormalities in BTBR Mice and Their Relevance to Schizophrenia and Autism Spectrum Disorders: An Overview of Transcriptomic and Proteomic Studies.Biomedicines · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The present study aims to investigate the functional brain network characteristics of preschool children with autism spectrum disorder (ASD) through functional connectivity (FC) calculations using resting-state functional MRI (rs-fMRI) and graph theory analysis to better understand the pathogenesis of ASD and provide imaging evidence for the early assessment of this condition. Methods: A prospective study of preschool children including 32 with ASD (ASD group) and 22 healthy controls (HC)group was conducted in which all subjects underwent rs-fMRI scans, and then the differences in FC between the two groups was calculated, followed by graph-theoretic analysis to obtain the FC properties of the network. Results: In the calculation of FC, compared with the children in the HC group, significant increases or decreases in subnetwork connectivity was found in the ASD group. There were 25 groups of subnetworks with enhanced FC, of which the medial prefrontal and posterior cingulate gyrus and angular gyrus were all important components of the default mode network (DMN). There were 11 groups of subnetworks with weakened FC, including the hippocampus, parahippocampal gyrus, superior frontal gyrus, inferior temporal gyrus, precuneus, amygdala, and perirhinal cortex, with the hippocampus and parahippocampal gyrus predominating. In the network properties determined by graph theory, the clustering coefficient and local efficiency of the functional network was increased in the ASD group; specifically, compared with those in the HC group, nodes in the left subinsular frontal gyrus and the right middle temporal gyrus had increased efficiency, and nodes in the left perisylvian cortex, the left lingual gyrus, and the right hippocampus had decreased efficiency. Conclusion: Alterations in functional brain networks are evident in preschool children with ASD and can be detected with sleep rs-fMRI, which is important for understanding the pathogenesis of ASD and assessing this condition early.
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