Evidence map›Paper›PMID 35859544›Full record

ReviewNeuro-oncology practice2022

Inherited genetics of adult diffuse glioma and polygenic risk scores-a review.

Jeanette E Eckel-Passow, Daniel H Lachance, Paul A Decker, Thomas M Kollmeyer, Matthew L Kosel, Kristen L Drucker, Susan Slager, Margaret Wrensch, W Oliver Tobin, Robert B Jenkins

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuro-oncology practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Genome-wide Polygenic Risk Scores Predict Risk of Glioma and Molecular Subtypes.medRxiv : the preprint server for health sciences · 2024
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jeanette E Eckel-PassowDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Daniel H LachanceDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Paul A DeckerDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Thomas M KollmeyerDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Matthew L KoselDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Kristen L DruckerDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Susan SlagerDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Margaret WrenschDepartment of Neurological Surgery, Institute of Human Genetics, University of California, San Francisco, San Francisco, California, USA.
W Oliver TobinDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Robert B JenkinsDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0002-4049-694X
Mayo Clinic · USMayo Clinic in Florida · USUniversity of California, San Francisco · US

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3M
Immune epigenetic biomarkers of survival in glioma epidemiologyR01CA207360 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K. · 2017 to 2021
$3.8M
Diagnosis of indeterminate brain lesions using MRI-based machine learning and polygenic risk modelsR01NS113803 · NINDS · MAYO CLINIC ROCHESTER · PI ECKEL PASSOW, JEANETTE E, TOBIN, W. OLIVER · 2020 to 2024
$3.1M
NCCDPHP CDC HHS NU58DP006344NCI NIH HHS HHSN261201800009CNCI NIH HHS HHSN261201800009INCI NIH HHS HHSN261201800015CNCI NIH HHS HHSN261201800015INCI NIH HHS HHSN261201800032CNCI NIH HHS HHSN261201800032INCI NIH HHS P30 CA015083NCI NIH HHS R01 CA207360NINDS NIH HHS R01 NS113803
6 · The paper itself

Abstract

Knowledge about inherited and acquired genetics of adult diffuse glioma has expanded significantly over the past decade. Genomewide association studies (GWAS) stratified by histologic subtype identified six germline variants that were associated specifically with glioblastoma (GBM) and 12 that were associated with lower grade glioma. A GWAS performed using the 2016 WHO criteria, stratifying patients by

Indexed as

geneticsgliomapolygenicriskvariants

Identifiers

PMID35859544
PMCPMC9290891
OpenAlexW4221111823

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.