ArticleScientific reports2022
Calcium responses to external mechanical stimuli in the multicellular stage of Dictyostelium discoideum.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Enhancement of Skin Barrier Function Using DYNAMiQ Technology: A Clinical Evaluation.Journal of cosmetic dermatology · 2026Article
- Establishing functional giant Dictyostelium cells reveals front-rear polarity in intracellular signaling.Communications biology · 2026Article
- Review
- Effect of Retinal on Dictyostelium Cells During Development.Genes to cells : devoted to molecular & cellular mechanisms · 2025Article
- Two endogenousProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mechanical Modulation, Physiological Roles, and Imaging Innovations of Intercellular Calcium Waves in Living Systems.Cancers · 2025Review
- Cell-to-cell signaling in cell populations with large cell size variability.Biophysical journal · 2025Article
- Nuclear Envelope Dynamics inCells · 2025Review
- Ion Signaling in Cell Motility and Development inBiomolecules · 2024Review
- Mechanobiology: A landscape for reinterpreting stem cell heterogeneity and regenerative potential in diseased tissues.iScience · 2023Review
- Frontiers of microbial movement research.Biophysics and physicobiology · 2023Article
- Visualization of c-di-GMP in multicellularFrontiers in cell and developmental biology · 2023Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Calcium acts as a second messenger to regulate many cellular functions, including cell motility. In Dictyostelium discoideum, the cytosolic calcium level oscillates synchronously, and calcium waves propagate through the cell population during the early stages of development, including aggregation. In the unicellular phase, the calcium response through Piezo channels also functions in mechanosensing. However, calcium dynamics during multicellular morphogenesis are still unclear. Here, live imaging of cytosolic calcium revealed that calcium wave propagation, depending on cAMP relay, disappeared at the onset of multicellular body (slug) formation. Later, other forms of occasional calcium bursts and their propagation were observed in both anterior and posterior regions of migrating slugs. This calcium signaling also occurred in response to mechanical stimuli. Two pathways-calcium release from the endoplasmic reticulum via IP3 receptor and calcium influx from outside the cell-were involved in calcium signals induced by mechanical stimuli. These data suggest that calcium signaling is involved in mechanosensing in both the unicellular and multicellular phases of Dictyostelium development using different molecular mechanisms.
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