Evidence map›Paper›PMID 35858992›Full record

ArticleMolecular psychiatry2022

Evaluation of in vivo staging of amyloid deposition in cognitively unimpaired elderly aged 78-94.

Malgorzata M Michalowska, Karl Herholz, Rainer Hinz, Chinenye Amadi, Lynn McInnes, Jose M Anton-Rodriguez, Thomas K Karikari, Kaj Blennow, Henrik Zetterberg, Nicholas J Ashton and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Alzheimer's Amyloid Hypothesis and Antibody Therapy: Melting Glaciers?International journal of molecular sciences · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 5 countries.

Malgorzata M MichalowskaWolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0001-5946-123X
Karl HerholzWolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-8658-0151
Rainer HinzWolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-7808-9207
Chinenye AmadiWolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.
Lynn McInnesDepartment of Psychology, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0001-7660-2284
Jose M Anton-RodriguezWolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.
Thomas K KarikariDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.ORCID http://orcid.org/0000-0003-1422-4358
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.ORCID http://orcid.org/0000-0003-3930-4354
Nicholas J AshtonDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Neil PendletonDivision of Neuroscience and Experimental Psychology, University of Manchester, Manchester, UK.
Stephen F CarterWolfson Molecular Imaging Centre, University of Manchester, Manchester, UK. Stephen.f.carter@manchester.ac.uk.ORCID http://orcid.org/0000-0002-9080-519X
University of Manchester · GBSahlgrenska University Hospital · SEKarolinska Institutet · SEKing's College London · GBNorthumbria University · GBUniversity of Cambridge · GBUniversity of Pittsburgh · US

Funding

Department of Health BRC-1215-20014
6 · The paper itself

Abstract

Amyloid-beta (Aβ) deposition is common in cognitively unimpaired (CU) elderly >85 years. This study investigated amyloid distribution and evaluated three published in vivo amyloid-PET staging schemes from a cognitively unimpaired (CU) cohort aged 84.9 ± 4.3 years (n = 75). SUV-based principal component analysis (PCA) was applied to

Indexed as

Alzheimer DiseaseAmyloidosisAgedAged, 80 and overAmyloid beta-PeptidesBrainHumansPositron-Emission TomographyAmyloid beta-Peptides

Identifiers

PMID35858992
PMCPMC9718666
OpenAlexW4285900099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.