ArticleBMC medical genomics2022
Identification of biomarkers related to neutrophils and two molecular subtypes of systemic lupus erythematosus.
Article in BMC medical genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The molecular subtypes of autoimmune diseases.Computational and structural biotechnology journal · 2024Review
- How Co-Stimulatory/Inhibitory Molecules Vary Across Immune Cell Subtypes in the Severity of Systemic Lupus Erythematosus Compared to Controls.Biomedicines · 2024Article
- Development and validation of an artificial intelligence model for the early classification of the aetiology of meningitis and encephalitis: a retrospective observational study.EClinicalMedicine · 2023Article
- A comprehensive review ofFrontiers in pharmacology · 2023Review
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Authors and funding
2 authors.
Funding
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Abstract
backgroundSystemic lupus erythematosus (SLE), an autoimmune disease with complex pathogenesis, poses a considerable threat to women's health. Increasing evidence indicates that neutrophils play an important role in the development and progression of lupus.
methodsWeighted correlation network analysis and single-sample gene set enrichment analysis (GSEA) were used to analyse SLE expression data from a comprehensive gene expression database and identify modules associated with neutrophils. Thereafter, the biomarkers most closely related to neutrophils were identified. We reclassified SLE into two molecular subtypes based on the aforementioned biomarkers and evaluated cell infiltration, molecular mechanisms, and signature pathways in each subtype.
resultsThe results showed significant differences in immunological characteristics between the two molecular subtypes of SLE. Hub genes were significantly upregulated in the NEUT-H subtype, and they may be associated with lupus activity. The GSEA revealed associations between our biomarkers and key metabolic pathways.
conclusionsOur study provides not only a classification for patients with SLE but also new cell and gene targets for immunotherapy, as well as a new experimental paradigm to explore immunotherapy for other autoimmune diseases.
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