ArticleBMC rheumatology2022
Incidence, remission, and persistence of Raynaud's phenomenon in the general population of northern Sweden: a prospective study.
Article in BMC rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07112183 (An Open Label Study to Assess Efficacy of Oral Treprostinil Titrated to 3.0mg Three Times Daily or Highest Tolerable Dose in 30 Patients With Symptomatic Primary or Secondary Raynaud's Phenomenon Resistant to Standard Vasodilatory Therapy), which is not on this map. Cited by 9 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Open Label Study to Assess Efficacy of Oral Treprostinil Titrated to 3.0mg Three Times Daily or Highest Tolerable Dose in 30 Patients With Symptomatic Primary or Secondary Raynaud's Phenomenon Resistant to Standard Vasodilatory Therapy
Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Thermal comfort, health, and performance effects among outdoor workers in northern Sweden.Annals of work exposures and health · 2026Article
- An epidemiological study estimating the burden of cancer risk in patients with Raynaud's phenomenon.Clinical rheumatology · 2026Article
- Local cold injury affecting the hand and incident Raynaud's phenomenon - a case report.International journal of circumpolar health · 2025Article
- The role of personal risk factors in the occurrence of the hand-arm vibration syndrome: a pooled analysis of individual data from Italian cross-sectional and cohort studies.International archives of occupational and environmental health · 2025Article
- A roadmap for assessing the diagnostic usefulness of neurosensory testing and an updated method for exposure assessment among vibration-exposed workers in northern Sweden.International journal of circumpolar health · 2024Article
- Serum biomarkers in patients with hand-arm vibration injury and in controls.Scientific reports · 2024Article
- Neurosensory and vascular symptoms and clinical findings in the hands of Arctic open-pit miners in Sweden and Norway - a descriptive study.International journal of circumpolar health · 2023Article
- Dynamic blood flow imaging withScientific reports · 2023Article
- Occupational cold exposure is associated with upper extremity pain.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRaynaud's phenomenon is common condition, but little is known about the natural course. The primary aim of this study was to determine the incidence, remission, and persistence proportions of Raynaud's phenomenon in the general population of northern Sweden. Secondary aims were to determine how individual and exposure factors affect the course of Raynaud's phenomenon, and to assess gender differences.
methodsA prospective, survey-based, closed-cohort study was conducted on a sample of men and women between 18-70 years of age, living in northern Sweden. Data on Raynaud's phenomenon characteristics and general health status were collected during the winters of 2015 (baseline) and 2021 (follow-up). Rates of incidence, remission, and persistence were calculated. Binary logistic regression was used to determine the association between baseline variables and the course of Raynaud's phenomenon.
resultsThe study population consisted of 2703 women (53.9%) and 2314 men. There were 390 women (14.5%) and 290 men (12.7%) reporting Raynaud's phenomenon in the follow-up survey. The annual incidence proportion was 0.7% among women and 0.9% among men (gender difference p = 0.04). The annual remission proportion was 4.4% and 5.5%, respectively (p = 0.05). Having sustained a cold injury affecting the hands since baseline was significantly associated with incident Raynaud's phenomenon (OR 3.92; 95% CI 2.60-5.90), after adjusting for age and gender.
conclusionsIn the general population of northern Sweden, Raynaud's phenomenon is a common but variable condition, where symptoms may remit over time. Men had a higher incidence proportion than women. The results support a possible causal pathway where cold injury can precede the onset of Raynaud's phenomenon.
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