Evidence map›Paper›PMID 35858899›Full record

Observational studyCritical care (London, England)2022

Long-term cognitive functioning is impaired in ICU-treated COVID-19 patients: a comprehensive controlled neuropsychological study.

Henriikka Ollila, Riikka Pihlaja, Sanna Koskinen, Annamari Tuulio-Henriksson, Viljami Salmela, Marjaana Tiainen, Laura Hokkanen, Johanna Hästbacka

Registry-linked trialOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04864938 (Recovery After Critical Covid-19 Infection), which is not on this map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04864938 unknown statusnot on this map

Recovery After Critical Covid-19 Infection

TypeobservationalSponsorUniversity of HelsinkiRan2020 to 2024Enrolled250ConditionsCovid-19
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Henriikka OllilaDepartment of Anaesthesiology, Intensive Care and Pain Medicine, Helsinki University Hospital and University of Helsinki, Helsinki, Finland. henriikka.ollila@helsinki.fi.ORCID 0000-0002-0833-5644
Riikka PihlajaDepartment of Psychology and Logopaedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0001-8724-5227
Sanna KoskinenDepartment of Psychology and Logopaedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-3453-5084
Annamari Tuulio-HenrikssonDepartment of Psychology and Logopaedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-3580-3693
Viljami SalmelaDepartment of Psychology and Logopaedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0001-7218-5321
Marjaana TiainenDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID 0000-0001-5107-1990
Laura Hokkanen *Department of Psychology and Logopaedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0001-8342-9248
Johanna Hästbacka *Department of Anaesthesiology, Intensive Care and Pain Medicine, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID 0000-0002-3613-7231
University of Helsinki · FI

Funding

Helsingin ja Uudenmaan Sairaanhoitopiiri TYH2021310
6 · The paper itself

Abstract

backgroundCognitive impairment has emerged as a common post-acute sequela of coronavirus disease 2019 (COVID-19). We hypothesised that cognitive impairment exists in patients after COVID-19 and that it is most severe in patients admitted to the intensive care unit (ICU).

methodsThis prospective controlled cohort study of 213 participants performed at the Helsinki University Hospital and the University of Helsinki, Finland, comprised three groups of patients-ICU-treated (n = 72), ward-treated (n = 49), and home-isolated (n = 44)-with confirmed COVID-19 between March 13 and December 31, 2020, participating in a comprehensive neuropsychological evaluation six months after the acute phase. Our study included a control group with no history of COVID-19 (n = 48). Medical and demographic data were collected from electronic patient records and interviews carried out four months after the acute phase. Questionnaires filled six months after the acute phase provided information about change in cognitive functioning observed by a close informant, as well as the presence of self-reported depressive and post-traumatic symptoms.

resultsThe groups differed (effect size η

conclusionsICU-treated COVID-19 patients, compared to patients with less severe acute COVID-19 or non-COVID controls, showed more severe long-term cognitive impairment. Among those with more than 12 years of education, impairment existed particularly in the domains of attention and for men, of executive functions. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov NCT04864938, retrospectively registered February 9, 2021.

Indexed as

Cognitive DysfunctionCOVID-19CognitionCohort StudiesHumansIntensive Care UnitsMaleProspective StudiesCognitive functioningCognitive impairmentCOVID-19Intensive care unitLong-term outcome

Identifiers

PMID35858899
PMCPMC9297673
OpenAlexW4286001157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.