Evidence map›Paper›PMID 35858873›Full record

ArticleJournal of nanobiotechnology2022

GRP75-driven, cell-cycle-dependent macropinocytosis of Tat/pDNA-Ca

Linjia Su, Zhe Sun, Fangzheng Qi, Huishan Su, Luomeng Qian, Jing Li, Liang Zuo, Jinhai Huang, Zhilin Yu, Jinping Li and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Lysophosphatidic acid-induced Arf6-driven macropinocytosis of CD147International journal of biological sciences · 2026
    Article
  4. 27-Hydroxycholesterol in cancer development and drug resistance.Journal of enzyme inhibition and medicinal chemistry · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Linjia Su *Department of Cell Biology, School of Medicine, Nankai University, Nankai District, 94 Weijin Road, Tianjin, 300071, People's Republic of China.
Zhe Sun *School of Life Sciences, Tianjin University, Weijin Road 92, Tianjin, 300072, China.
Fangzheng Qi *Department of Cell Biology, School of Medicine, Nankai University, Nankai District, 94 Weijin Road, Tianjin, 300071, People's Republic of China.
Huishan Su *Department of Cell Biology, School of Medicine, Nankai University, Nankai District, 94 Weijin Road, Tianjin, 300071, People's Republic of China.
Luomeng QianDepartment of Cell Biology, School of Medicine, Nankai University, Nankai District, 94 Weijin Road, Tianjin, 300071, People's Republic of China.
Jing LiDepartment of Cell Biology, School of Medicine, Nankai University, Nankai District, 94 Weijin Road, Tianjin, 300071, People's Republic of China.
Liang ZuoDepartment of Cell Biology, School of Medicine, Nankai University, Nankai District, 94 Weijin Road, Tianjin, 300071, People's Republic of China.
Jinhai HuangSchool of Life Sciences, Tianjin University, Weijin Road 92, Tianjin, 300072, China.
Zhilin YuState Key Laboratory of Medicinal Chemical Biology, College of Chemistry, Nankai University, Weijin Road 94, Tianjin, 300071, China.
Jinping LiDepartment of Medical Biochemistry and Microbiology, Uppsala University, 75123, Uppsala, Sweden.
Zhinan ChenNational Translational Science Center for Molecular Medicine, Department of Cell Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an, 710032, China.
Sihe ZhangDepartment of Cell Biology, School of Medicine, Nankai University, Nankai District, 94 Weijin Road, Tianjin, 300071, People's Republic of China. sihezhang@nankai.edu.cn.
Nankai University · CNTianjin University · CNUppsala University · SEAir Force Medical University · CN

Funding

Chinese Pharmacertical Association-Yiling Pharmacertical Innovation Fund CPAYLJ202003Key Research and Development Program of Tianjin 20YFZCSY00450Key Research Fund of Tianjin Project & Team XB202010National Natural Science Foundation of China 81373318National Translational Science Center for Molecular Medicine Fund F1034361Tianjin sci-tech commissioner Fund 21YDTPJC00220
6 · The paper itself

Abstract

Practice of tumor-targeted suicide gene therapy is hampered by unsafe and low efficient delivery of plasmid DNA (pDNA). Using HIV-Tat-derived peptide (Tat) to non-covalently form Tat/pDNA complexes advances the delivery performance. However, this innovative approach is still limited by intracellular delivery efficiency and cell-cycle status. In this study, Tat/pDNA complexes were further condensed into smaller, nontoxic nanoparticles by Ca

Indexed as

NanoparticlesOvarian NeoplasmsAnimalsCalciumDNAFemaleGenetic TherapyGene Transfer TechniquesHSP70 Heat-Shock ProteinsHumansMembrane ProteinsMicePlasmidsTransfectionCalciumDNAglucose-regulated proteinsHSP70 Heat-Shock ProteinsMembrane ProteinsCell-cycleGlucose-regulated proteinMacropinocytosisOvarian cancerSuicide gene therapyTat/pDNA-Ca2+ nanoparticle

Identifiers

PMID35858873
PMCPMC9301890
OpenAlexW4286008897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.