Evidence map›Paper›PMID 35858738›Full record

ArticleBMJ case reports2022

Recognising immunotherapy-induced meningoencephalitis: a case during treatment for primary metastatic melanoma of the bladder neck.

Joel Grunhut, Shimron Brown, Jose Lutzky, Leor Skoczylas

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Joel GrunhutIntegrated Medical Science, Florida Atlantic University Charles E Schmidt College of Medicine, Boca Raton, Florida, USA jgrunhut2019@health.fau.edu.ORCID http://orcid.org/0000-0002-8104-9679
Shimron BrownIntegrated Medical Science, Florida Atlantic University Charles E Schmidt College of Medicine, Boca Raton, Florida, USA.
Jose LutzkyMedical Oncology, Sylvester Comprehensive Cancer Center, Miami, Florida, USA.
Leor SkoczylasIntegrated Medical Science, Florida Atlantic University Charles E Schmidt College of Medicine, Boca Raton, Florida, USA.
Florida Atlantic University · USSylvester Comprehensive Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although novel immunotherapy has shown promise for patients with melanoma, a more activated state of the immune system may lead to adverse systemic effects. Immunotherapy-induced meningoencephalitis is a rare and seldom reported adverse effect of immunotherapy but with the expanding role of immunotherapy in cancer treatments it must be recognised. Patients receiving immunotherapy should receive a proper warning about the potential for this life-threatening condition. Herein, we report a patient in his 70s with neurological changes after his second treatment with dual immunotherapy for a primary metastatic melanoma of the bladder neck.

Indexed as

Drug-Related Side Effects and Adverse ReactionsMelanomaMeningoencephalitisNeoplasms, Second PrimarySkin NeoplasmsHumansImmunologic FactorsImmunotherapyUrinary BladderImmunologic FactorsCancer interventionEndocrine systemMalignant disease and immunosuppressionMedical managementUrological cancer

Identifiers

PMID35858738
PMCPMC9305691
OpenAlexW4286254641

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.