ArticleThe Journal of antimicrobial chemotherapy2022
Molecular ecology and risk factors for third-generation cephalosporin-resistant Escherichia coli carriage by dogs living in urban and nearby rural settings.
Article in The Journal of antimicrobial chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Risk factors for antimicrobial-resistantFrontiers in veterinary science · 2024Pooled it
- Genomic epidemiology to investigate the origins and zoonotic implications of antibiotic-resistantOne health (Amsterdam, Netherlands) · 2026Article
- Poultry-associated nitrofurantoin-resistant and pre-resistantOne health (Amsterdam, Netherlands) · 2025Article
- Environmental exposures and health outcomes in dogs differ according to geographic region in the United States among Dog Aging Project participants.American journal of veterinary research · 2025Article
- Blood biomarkers are altered in elderly hematological patients exhibiting a mosaic loss of the Y chromosome in bone marrow cells.BMC cancer · 2025Article
- The Risk Factors Associated with the Carriage to Critical Antimicrobial-ResistantAnimals : an open access journal from MDPI · 2025Article
- Dog and owner demographics impact dietary choices in Dog Aging Project cohort.Journal of the American Veterinary Medical Association · 2024Article
- Variables associated with owner perceptions of the health of their dog: Further analysis of data from a large international survey.PloS one · 2024Article
- Raw meat diets are a major risk factor for carriage of third-generation cephalosporin-resistant and multidrug-resistantFrontiers in microbiology · 2024Article
- One health transmission of fluoroquinolone-resistantOne health (Amsterdam, Netherlands) · 2023Article
- Molecular ecology of highest priority critically important antibiotic resistant Escherichia coli from mammals housed at an urban zoo.The Journal of antimicrobial chemotherapy · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo compare faecal third-generation cephalosporin-resistant (3GC-R) Escherichia coli isolates from dogs living in a city and in a rural area ∼30 km away; to compare isolates from dogs, cattle and humans in these regions; and to determine risk factors associated with 3GC-R E. coli carriage in these two cohorts of dogs.
methodsSix hundred dogs were included, with faecal samples processed to recover 3GC-R E. coli using 2 mg/L cefotaxime. WGS was by Illumina and risk factor analyses were by multivariable linear regression using the results of an owner-completed survey.
results3GC-R E. coli were excreted by 20/303 rural and 31/297 urban dogs. The dominant canine 3GC-R ST was ST963 (blaCMY-2), which also accounted for 25% of CMY-2-producing E. coli in humans. Phylogenetic overlap between cattle and rural dog CTX-M-14-producing E. coli ST117 was observed as well as acquisition of pMOO-32-positive E. coli ST10 by a rural dog, a plasmid common on cattle farms in the area. Feeding raw meat was associated with carrying 3GC-R E. coli in rural dogs, but not in urban dogs, where swimming in rivers was a weak risk factor.
conclusionsGiven clear zoonotic potential for resistant canine E. coli, our work suggests interventions that may reduce this threat. In rural dogs, carriage of 3GC-R E. coli, particularly CTX-M producers, was phylogenetically associated with interaction with local cattle and epidemiologically associated with feeding raw meat. In urban dogs, sources of 3GC-R E. coli appear to be more varied and include environments such as rivers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.