Evidence map›Paper›PMID 35858453›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Adaptive laboratory evolution and independent component analysis disentangle complex vancomycin adaptation trajectories.

Anaëlle Fait, Yara Seif, Kasper Mikkelsen, Saugat Poudel, Jerry M Wells, Bernhard O Palsson, Hanne Ingmer

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Evolution under vancomycin selection drives divergent collateral sensitivity patterns inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Phenotypic and genetic stepwise changes inAntimicrobial agents and chemotherapy · 2025
    Article
  7. The Secondary Resistome of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Adaptive Laboratory Evolution ofAntibiotics (Basel, Switzerland) · 2023
    Article
  13. Subpopulations in Strains ofAntibiotics (Basel, Switzerland) · 2023
    Review
  14. Adaptive laboratory evolution and independent component analysis disentangle complex vancomycin adaptation trajectories.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Anaëlle FaitDepartment of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, 1870 Denmark.ORCID 0000-0002-0341-5426
Yara SeifDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0001-8813-5679
Kasper MikkelsenDepartment of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, 1870 Denmark.ORCID 0000-0001-6062-4243
Saugat PoudelDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0002-3732-2463
Jerry M WellsHost-Microbe Interactomics, Animal Sciences Group, Wageningen University, Wageningen, The Netherlands.
Bernhard O PalssonDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0003-2357-6785
Hanne IngmerDepartment of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, 1870 Denmark.ORCID 0000-0002-8350-5631
University of Copenhagen · DKUniversity of California San Diego · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USWageningen University & Research · NL

Funding

Systems Biology Approach to Redefine Susceptibility Testing and Treatment of MDR Pathogens in the Context of Host ImmunityU01AI124316 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PALSSON, BERNHARD O · 2016 to 2020
$10.2M
NIAID NIH HHS U01 AI124316
6 · The paper itself

Abstract

Human infections with methicillin-resistant

Indexed as

Anti-Bacterial AgentsMethicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsStaphylococcus aureusVancomycinVancomycin ResistanceEvolution, MolecularHumansMicrobial Sensitivity TestsOxacillinVirulenceAnti-Bacterial AgentsOxacillinVancomycinadaptive laboratory evolutionantibiotic resistancetranscriptional regulationvirulence

Identifiers

PMID35858453
PMCPMC9335240
OpenAlexW4285798129

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.