Evidence map›Paper›PMID 35858452›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Structural basis for high-voltage activation and subtype-specific inhibition of human Na

Xiaoshuang Huang, Xueqin Jin, Gaoxingyu Huang, Jian Huang, Tong Wu, Zhangqiang Li, Jiaofeng Chen, Fang Kong, Xiaojing Pan, Nieng Yan

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

  1. Electrostatic tuning of NaThe Journal of physiology · 2026
    Article
  2. Article
  3. Article
  4. Short Cationic ACTH-Related Peptides Can Modulate the NaInternational journal of molecular sciences · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Targeting NaInternational journal of molecular sciences · 2026
    Review
  9. Suzetrigine, a NaMolecules (Basel, Switzerland) · 2026
    Review
  10. Article
  11. Review
  12. MOG1medRxiv : the preprint server for health sciences · 2025
    Article
  13. Toward Brain NaPharmaceuticals (Basel, Switzerland) · 2025
    Article
  14. Article
  15. Review
  16. Critical role of extracellular loops in differential modulations of TTX-sensitive and TTX-resistant NaProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. Review
  19. Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoshuang HuangState Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Xueqin JinState Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Gaoxingyu HuangWestlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou 310024, China.
Jian HuangState Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Tong WuState Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Zhangqiang LiState Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Jiaofeng ChenState Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Fang KongState Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Xiaojing PanState Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Nieng YanState Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.ORCID 0000-0003-4829-7416

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dorsal root ganglia-localized voltage-gated sodium (Na

Indexed as

Aniline CompoundsFuransNAV1.7 Voltage-Gated Sodium ChannelVoltage-Gated Sodium Channel BlockersAllosteric RegulationCryoelectron MicroscopyHumansMembrane PotentialsProtein DomainsA 803467Aniline CompoundsFuransNAV1.7 Voltage-Gated Sodium ChannelVoltage-Gated Sodium Channel Blockerscryo-EM structureelectromechanical couplingNav1.8subtype-specific Nav blockervoltage sensing

Identifiers

PMID35858452
PMCPMC9335304

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.