ArticleProceedings of the National Academy of Sciences of the United States of America2022
Proton transfer activity of the reconstituted
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
What it found
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- Structure, assembly, and mechanism of the MmpL family of transporters.Microbiology and molecular biology reviews : MMBR · 2026Review
- Bacterial cell envelope-targeting antibiotics.Nature reviews. Microbiology · 2026Review
- Protective mechanism of action of the antifungal drug naftifine againstAntimicrobial agents and chemotherapy · 2026Article
- MmpL12 transports lipooligosaccharides and impacts virulence inMicrobiology (Reading, England) · 2025Article
- Microbiological evidence for the trisubstituted benzimidazoles targeting MmpL3 inAntimicrobial agents and chemotherapy · 2025Article
- Common Biological Properties ofACS infectious diseases · 2025Article
- A coiled-coil domain triggers oligomerization of MmpL10, the mycobacterial transporter of trehalose polyphleate precursor.FEBS letters · 2025Article
- Structural modeling and characterization of the Mycobacterium tuberculosis MmpL3 C-terminal domain.FEBS letters · 2024Article
- Allosteric coupling of substrate binding and proton translocation in MmpL3 transporter frommBio · 2024Article
- Inhibitor binding and disruption of coupled motions in MmpL3 protein: Unraveling the mechanism of trehalose monomycolate transport.Protein science : a publication of the Protein Society · 2024Article
- Structural and functional diversity of Resistance-Nodulation-Division (RND) efflux pump transporters with implications for antimicrobial resistance.Microbiology and molecular biology reviews : MMBR · 2024Review
- The mycobacterium lipid transporter MmpL3 is dimeric in detergent solution, SMALPs and reconstituted nanodiscs.RSC chemical biology · 2024Article
- Structural analysis of resistance-nodulation cell division transporters.Microbiology and molecular biology reviews : MMBR · 2024Review
- Mycobacterium tuberculosis suppresses host antimicrobial peptides by dehydrogenating L-alanine.Nature communications · 2024Article
- Recent advances in mycobacterial membrane protein large 3 inhibitor drug design for mycobacterial infections.Expert opinion on drug discovery · 2023Review
- Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria.Journal of medicinal chemistry · 2023Article
- Insights into substrate transport and water permeation in the mycobacterial transporter MmpL3.Biophysical journal · 2023Article
- Study of SQ109 analogs binding to mycobacterium MmpL3 transporter using MD simulations and alchemical relative binding free energy calculations.Journal of computer-aided molecular design · 2023Article
- Structural Determinants of Indole-2-carboxamides: Identification of Lead Acetamides with Pan Antimycobacterial Activity.Journal of medicinal chemistry · 2023Article
- Cryo-EM structure of the trehalose monomycolate transporter, MmpL3, reconstituted into peptidiscs.Current research in structural biology · 2023Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Casey M StevensDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019.ORCID 0000-0003-4411-7182
Svitlana O BabiiDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019.ORCID 0000-0002-2304-9144
Amitkumar N PandyaSchool of Pharmacy & Health Professions, Department of Pharmacy Sciences, Creighton University, Omaha, NE 68178.ORCID 0000-0001-6027-2460
Wei LiMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523.ORCID 0000-0001-6430-5610
Yupeng LiCollege of Chemistry, Jilin University, 130012 Changchun, China.
Jitender MehlaDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019.ORCID 0000-0002-7829-557X
Robyn ScottSchool of Pharmacy & Health Professions, Department of Pharmacy Sciences, Creighton University, Omaha, NE 68178.ORCID 0000-0001-6450-4708
Pooja HegdeSchool of Pharmacy & Health Professions, Department of Pharmacy Sciences, Creighton University, Omaha, NE 68178.ORCID 0000-0003-1474-1339
Pavan K PrathipatiSchool of Pharmacy & Health Professions, Department of Pharmacy Sciences, Creighton University, Omaha, NE 68178.ORCID 0000-0002-2463-3350
Atanu AcharyaSchool of Physics, Georgia Institute of Technology, Atlanta, GA 30332.ORCID 0000-0002-6960-7789
Jinchan LiuCollege of Chemistry, Jilin University, 130012 Changchun, China.
James C GumbartSchool of Physics, Georgia Institute of Technology, Atlanta, GA 30332.
Jeffrey NorthSchool of Pharmacy & Health Professions, Department of Pharmacy Sciences, Creighton University, Omaha, NE 68178.
Mary JacksonMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523.ORCID 0000-0002-9212-0258
Helen I ZgurskayaDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019.ORCID 0000-0001-8929-4727
Creighton University · USGeorgia Institute of Technology · USUniversity of Oklahoma · USColorado State University · US
Funding
MmpL3 as a target for novel anti-TB agentsR01AI116525 · NIAID · COLORADO STATE UNIVERSITY · PI JACKSON, MARY · 2015 to 2024
$5.3MBiacore T200S10OD025014 · OD · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI MCEVER, RODGER PAUL · 2018 to 2018
$322kNIAID NIH HHS R01 AI116525NIH HHS S10 OD025014
Abstract
Transporters belonging to the Resistance-Nodulation-cell Division (RND) superfamily of proteins such as
Indexed as
Bacterial ProteinsMembrane Transport ProteinsCorynebacteriumIon TransportLipid BilayersMycolic AcidsProtonsSubstrate SpecificityBacterial ProteinsLipid BilayersMembrane Transport ProteinsMmpL3 protein, Mycobacterium tuberculosisMycolic AcidsProtonsdrug targetmembrane transporterreconstitutiontuberculosis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.