ArticleProceedings of the National Academy of Sciences of the United States of America2022
Behavioral genetics and genomics: Mendel's peas, mice, and bees.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Genetic and striatal structural connection linking behavioral inhibition/activation system to adolescent anxiety and depression.Translational psychiatry · 2025Article
- Permission to Bite: White-footed mice show no increased grooming response to tick infestation.Journal of zoology (London, England : 1987) · 2025Article
- The number of drones to inseminate a queen with has little potential for optimization of honeybee breeding programs.Hereditas · 2024Article
- Brain Gene Regulatory Networks Coordinate Nest Construction in Birds.Molecular biology and evolution · 2024Article
- Genetic variants that modify neuroendocrine gene expression and foraging behavior ofScience advances · 2024Article
- The genetic architecture of behavioral canalization.Trends in genetics : TIG · 2023Review
- Genetics of behavioural evolution in giant mice from Gough Island.Proceedings. Biological sciences · 2023Article
- Anemonefishes: A model system for evolutionary genomics.F1000Research · 2023Review
- Gregor Johann Mendel and the development of modern evolutionary biology.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genetics of adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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Authors and funding
2 authors at 2 institutions in 1 country.
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Abstract
The question of the heritability of behavior has been of long fascination to scientists and the broader public. It is now widely accepted that most behavioral variation has a genetic component, although the degree of genetic influence differs widely across behaviors. Starting with Mendel's remarkable discovery of "inheritance factors," it has become increasingly clear that specific genetic variants that influence behavior can be identified. This goal is not without its challenges: Unlike pea morphology, most natural behavioral variation has a complex genetic architecture. However, we can now apply powerful genome-wide approaches to connect variation in DNA to variation in behavior as well as analyses of behaviorally related variation in brain gene expression, which together have provided insights into both the genetic mechanisms underlying behavior and the dynamic relationship between genes and behavior, respectively, in a wide range of species and for a diversity of behaviors. Here, we focus on two systems to illustrate both of these approaches: the genetic basis of burrowing in deer mice and transcriptomic analyses of division of labor in honey bees. Finally, we discuss the troubled relationship between the field of behavioral genetics and eugenics, which reminds us that we must be cautious about how we discuss and contextualize the connections between genes and behavior, especially in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.