Evidence map›Paper›PMID 35858312›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Two distinct evolutionary conserved neural degeneration pathways characterized in a colonial chordate.

Chiara Anselmi, Mark Kowarsky, Fabio Gasparini, Federico Caicci, Katherine J Ishizuka, Karla J Palmeri, Tal Raveh, Rahul Sinha, Norma Neff, Stephen R Quake and 3 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Electrical stimulation promotes longevity and regeneration in a colonial chordate.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Sensory cells in tunicates: insights into mechanoreceptor evolution.Frontiers in cell and developmental biology · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Neuroprotection and Non-Invasive Brain Stimulation: Facts or Fiction?International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Chiara AnselmiStanford University, Hopkins Marine Station, Pacific Grove, CA 93950.
Mark KowarskyDepartment of Physics, Stanford University, Stanford, CA 94305.ORCID 0000-0001-5180-5683
Fabio GaspariniDipartimento di Biologia, Università degli Studi di Padova, 35131, Padova, Italy.
Federico CaicciDipartimento di Biologia, Università degli Studi di Padova, 35131, Padova, Italy.
Katherine J IshizukaStanford University, Hopkins Marine Station, Pacific Grove, CA 93950.
Karla J PalmeriStanford University, Hopkins Marine Station, Pacific Grove, CA 93950.
Tal RavehInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Rahul SinhaInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Norma NeffChan Zuckerberg Biohub, San Francisco CA 94158.ORCID 0000-0001-7141-5420
Stephen R QuakeChan Zuckerberg Biohub, San Francisco CA 94158.
Irving L WeissmanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-9077-7467
Ayelet VoskoboynikStanford University, Hopkins Marine Station, Pacific Grove, CA 93950.
Lucia ManniDipartimento di Biologia, Università degli Studi di Padova, 35131, Padova, Italy.
Chan Zuckerberg Initiative (United States) · USPacific University · USStanford University · USUniversity of Padua · IT

Funding

Genes, cells, and pathways that regulate urochordate allogeneic stem cell competition and their mammalian homologuesR01GM100315 · NIGMS · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2012 to 2019
$2.8M
Cellular and molecular mechanisms of aging and regeneration in colonial chordateR01AG037968 · NIA · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2010 to 2014
$1.5M
Evolutionary Conserved Mechanisms of Neuronal Degeneration and RegenerationR21AG062948 · NIA · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2020 to 2020
$434k
NIA NIH HHS R01 AG037968NIA NIH HHS R21 AG062948NIGMS NIH HHS R01 GM100315
6 · The paper itself

Abstract

Colonial tunicates are marine organisms that possess multiple brains simultaneously during their colonial phase. While the cyclical processes of neurogenesis and neurodegeneration characterizing their life cycle have been documented previously, the cellular and molecular changes associated with such processes and their relationship with variation in brain morphology and individual (zooid) behavior throughout adult life remains unknown. Here, we introduce

Indexed as

Biological EvolutionNeurodegenerative DiseasesUrochordataAnimalsGene ExpressionReproduction, Asexualagingcolonial chordateneural stem cellsneurodegenerationregeneration

Identifiers

PMID35858312
PMCPMC9303981
OpenAlexW4285005859

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.