ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2022
Interplay between the oxytocin and opioid systems in regulating social behaviour.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Oxytocin receptor gene expression in the basal forebrain in autism: association with receptor binding levels and single nucleotide polymorphisms.Journal of neurodevelopmental disorders · 2026Article
- Exploring wanting and liking during positive human-animal interactions.Psychopharmacology · 2026Article
- Updated Freudian drive theory: childhood trauma, epigenetics, serotonin and beta endorphin.Frontiers in psychiatry · 2026Article
- Oxytocin receptor gene expression in the basal forebrain in autism: association with receptor binding levels and single nucleotide polymorphisms.Research square · 2025Article
- A transdiagnostic approach to understanding neural responsivity to reward and its links to social motivation.Schizophrenia research. Cognition · 2025Article
- Oxytocin and opioid antagonists: A dual approach to improving social behavior.Annals of the New York Academy of Sciences · 2025Review
- Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation.Research square · 2025Article
- Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation.bioRxiv : the preprint server for biology · 2025Article
- How does oxytocin modulate human behavior?Molecular psychiatry · 2025Review
- Group singing and its effect on cortisol, alpha amylase, oxytocin, and pain threshold in patients with Parkinson's disease.Frontiers in neuroscience · 2025Article
- The psychophysiology of music-based interventions and the experience of pain.Frontiers in psychology · 2024Review
- Metabolites: a converging node of host and microbe to explain meta-organism.Frontiers in microbiology · 2024Review
- Love songs and serenades: a theoretical review of music and romantic relationships.Frontiers in psychology · 2024Article
- Emotions and courtship help bonded pairs cooperate, but emotional agents are vulnerable to deceit.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Oxytocin measurements in saliva: an analytical perspective.BMC veterinary research · 2023Review
- Tuning in to real-time social interactions in macaques.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Romantic love evolved by co-opting mother-infant bonding.Frontiers in psychology · 2023Article
- Oxytocin does not stand alone.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 4 countries.
Funding
Abstract
The influence of neuromodulators on brain activity and behaviour is undeniably profound, yet our knowledge of the underlying mechanisms, or ability to reliably reproduce effects across varying conditions, is still lacking. Oxytocin, a hormone that acts as a neuromodulator in the brain, is an example of this quandary; it powerfully shapes behaviours across nearly all mammalian species, yet when manipulated exogenously can produce unreliable or sometimes unexpected behavioural results across varying contexts. While current research is rapidly expanding our understanding of oxytocin, interactions between oxytocin and other neuromodulatory systems remain underappreciated in the current literature. This review highlights interactions between oxytocin and the opioid system that serve to influence social behaviour and proposes a parallel-mechanism hypothesis to explain the supralinear effects of combinatorial neuropharmacological approaches. This article is part of the theme issue 'Interplays between oxytocin and other neuromodulators in shaping complex social behaviours'.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.