ArticleScience translational medicine2022
Improving the diagnosis of severe malaria in African children using platelet counts and plasma
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In one paragraph
Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
8.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Cerebral malaria: of mice and men.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2026Pooled it
- The prognostic and diagnostic value of intraleukocytic malaria pigment in patients with severe falciparum malaria.Nature communications · 2022Pooled it
- Azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a phase II randomised controlled trial.BMC medicine · 2024Trial
- Prevalence of Plasmodium ovale and Plasmodium malariae Mixed Infections and Associated Mortality in Children with Severe Falciparum Malaria.The American journal of tropical medicine and hygiene · 2026Article
- Neurovascular Pathophysiology and Emerging Biomarkers in Cerebral Malaria: An Integrative Perspective.Neurology international · 2025Review
- Re-evaluating malarial retinopathy to improve its diagnostic accuracy in paediatric cerebral malaria: A retrospective study.PLoS medicine · 2025Article
- Aetiologies, neuroradiological features, and risk factors for mortality and long-term neurosequelae of febrile coma in Malawian children: a prospective cohort study.The Lancet. Global health · 2025Article
- Elevated uric acid levels, mortality and cognitive impairment in children with severe malaria.Nature medicine · 2025Article
- The role of immune-inflammatory markers in children with complicated and uncomplicated malaria in Enugu, Nigeria.BMC immunology · 2024Article
- The malarial blood transcriptome: translational applications.Biochemical Society transactions · 2024Review
- sTREM-1: A Biomarker of Mortality in Severe Malaria Impacted by Acute Kidney Injury.The Journal of infectious diseases · 2024Article
- The association of intraleucocytic malaria pigment and disease severity in Papua New Guinean children with severe P. falciparum malaria.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2023Article
- Rectal artesunate suppositories for the pre-referral treatment of suspected severe malaria.PLoS medicine · 2023Article
- Estimating the burden of severe malarial anaemia and access to hospital care in East Africa.Nature communications · 2023Article
- Severe Falciparum and Vivax Malaria on the Thailand-Myanmar Border: A Review of 1503 Cases.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Differential Effects of Antimalarial Drugs on Parasite Clearance Rates Are Reflected byOpen forum infectious diseases · 2023Article
- Histidine-rich protein II nanoparticle delivery of heme iron load drives endothelial inflammation in cerebral malaria.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The CARAMAL study could not assess the effectiveness of rectal artesunate in treating suspected severe malaria.BMC medicine · 2023Article
- Performance Analysis of Deep Learning Algorithms in Diagnosis of Malaria Disease.Diagnostics (Basel, Switzerland) · 2023Article
- Using Malarial Retinopathy to Improve the Diagnosis of Pediatric Cerebral Malaria.The American journal of tropical medicine and hygiene · 2023Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 5 countries.
James A WatsonMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.ORCID 0000-0001-5524-0325
Sophie UyogaKEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Coast, Kilifi 80108, Kenya.ORCID 0000-0003-1746-7873
Perpetual WanjikuKEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Coast, Kilifi 80108, Kenya.ORCID 0000-0001-9293-0181
Johnstone MakaleKEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Coast, Kilifi 80108, Kenya.ORCID 0000-0002-3670-7521
Gideon M NyutuKEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Coast, Kilifi 80108, Kenya.ORCID 0000-0002-5984-7690
Neema MturiKEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Coast, Kilifi 80108, Kenya.ORCID 0000-0002-6585-2074
Elizabeth C GeorgeMedical Research Council Clinical Trials Unit, University College London, London, UK.ORCID 0000-0002-2928-3580
Charles J WoodrowMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.ORCID 0000-0002-5134-7165
Nicholas P J DayMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.ORCID 0000-0003-2309-1171
Philip BejonCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-2135-7549
Robert O OpokaMakerere University, Department of Paediatrics and Child Health, Kampala, Uganda.
Arjen M DondorpMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.ORCID 0000-0001-5190-2395
Chandy C JohnDepartment of Pediatrics, Indiana University, Indiana, IN, USA.ORCID 0000-0002-1634-1411
Kathryn MaitlandKEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Coast, Kilifi 80108, Kenya.
Thomas N WilliamsKEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Coast, Kilifi 80108, Kenya.ORCID 0000-0003-4456-2382
Nicholas J WhiteMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.ORCID 0000-0002-1897-1978
Kenya Medical Research Institute · KEMahidol University · THIndiana University Health · USMakerere University · UGUniversity College London · GB
Funding
Severe Malaria And Risk to The Brain (SMART Brain)R01NS055349 · NINDS · UNIVERSITY OF MINNESOTA · PI Chandy C. John, Ruth Namazzi · 2008 to 2026
$11.2MMedical Research Council G0601027Medical Research Council G0801439Medical Research Council MC_UU_00004/05Medical Research Council MC_UU_12023/26NINDS NIH HHS R01 NS055349Wellcome Trust 093956/Z/10/CWellcome Trust 202800/Z/16/ZWellcome Trust 203077Wellcome Trust 209265/Z/17/ZWellcome Trust 221998/Z/20/ZWellcome Trust 223253/Z/21/Z
Abstract
Severe malaria caused by
Indexed as
MalariaMalaria, FalciparumAdultAntigens, ProtozoanBayes TheoremChildHumansPlasmodium falciparumPlatelet CountProtozoan ProteinsUgandaAntigens, ProtozoanProtozoan Proteins
Identifiers
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Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.