ArticleScience translational medicine2022
Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma.
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In one paragraph
Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
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The trial behind it
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Non-coding RNAs in drug and radiation resistance of bone and soft-tissue sarcoma: a systematic review.eLife · 2022Pooled it
- DHODH is the key target of the KDM4 inhibitor QC6352 in glioblastoma stem cells.Nature chemical biology · 2026Article
- Paediatric Therapeutic Development Workshop on rhabdomyosarcoma.British journal of cancer · 2026Review
- PAX3::FOXO1-Targeting PROTAC Induces Myogenic Differentiation of Fusion-Positive Rhabdomyosarcoma Cells.Cancers · 2026Article
- Dual inhibition of KDM4B and KDM5A disassembles the PAX3-FOXO1 transcriptional program in fusion-positive rhabdomyosarcoma.Biology direct · 2026Article
- Advances in targeted therapies for pediatric tumors.Acta pharmacologica Sinica · 2026Article
- Review
- Epigenetic reactivation of the tumor suppressor ZBTB7A by KDM4 inhibition in human acute myeloid leukemia.Science translational medicine · 2026Article
- Machine learning screening for disulfidptosis genes-associated immunosuppression status in osteosarcoma and rhabdomyosarcoma.Translational cancer research · 2025Article
- Enhancer regulator MLL4 controls skeletal muscle metabolic efficiency by limiting AMPK-mediated fuel catabolism.Nature communications · 2025Article
- Review
- Clinical characteristics and target exploration via scRNA-seq and high-throughput drug screening of FOXO1 fusion positive rhabdomyosarcoma.Pediatric surgery international · 2025Article
- Tumor-Immune Interactions in Pediatric Oral Rhabdomyosarcoma: A Narrative Review on Immuno-Oncology and Emerging Therapies.Children (Basel, Switzerland) · 2025Review
- Review
- Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics.Nature communications · 2025Article
- KDM4B enhances immune surveillance via demethylating cGAS.Cell death & disease · 2025Article
- Gene Fusions as Potential Therapeutic Targets in Soft Tissue Sarcomas.Biomolecules · 2025Review
- Molecular Targets in Alveolar Rhabdomyosarcoma: A Narrative Review of Progress and Pitfalls.International journal of molecular sciences · 2025Review
- Article
- Enhancer reprogramming: critical roles in cancer and promising therapeutic strategies.Cell death discovery · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
38 authors at 5 institutions in 2 countries.
Shivendra SinghDepartment of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0002-4153-8056
Ahmed Abu-ZaidDepartment of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0003-2286-2181
Hongjian JinCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0003-3833-7170
Jie FangDepartment of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Qiong WuDepartment of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0002-6063-0800
Tingting WangCenter for Childhood Cancer and Blood Disease, Abigail Wexner Research Institute, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.ORCID 0000-0002-6649-3114
Helin FengDepartment of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.ORCID 0000-0002-7260-5485
Waise QuarniDepartment of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0002-0202-5821
Ying ShaoDepartment of Computational Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Lily MaxhamDepartment of Computational Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Alireza AbdolvahabiDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Mi-Kyung YunDepartment of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0003-1213-5714
Sivaraja VaithiyalingamDepartment of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Haiyan TanDepartment of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0001-6687-2563
John BowlingDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0003-1045-3663
Victoria HonnellGraduate School of Biomedical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0003-2742-2951
Brandon YoungDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0003-2973-2072
Yian GuoDepartment of Biostatistics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0002-6091-6358
Richa BajpaiCenter for Advanced Genome Engineering, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Shondra M Pruett-MillerCenter for Advanced Genome Engineering, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0002-3793-585X
Gerard C GrosveldDepartment of Genetics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0002-6583-1265
Mark HatleyDepartment of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0001-7147-3946
Beisi XuCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0003-0099-858X
Yiping FanCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0002-8430-4620
Gang WuCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0002-1678-5864
Eleanor Y ChenDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.
Taosheng ChenDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0001-6420-3809
Peter W LewisDepartment of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.ORCID 0000-0002-9816-7823
Zoran RankovicDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Yimei LiDepartment of Biostatistics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0002-7046-4316
Andrew J MurphyDepartment of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0001-6747-0355
John EastonDepartment of Computational Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0003-4503-6608
Junmin PengDepartment of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0003-0472-7648
Xiang ChenDepartment of Computational Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0002-2499-8261
Ruoning WangCenter for Childhood Cancer and Blood Disease, Abigail Wexner Research Institute, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.ORCID 0000-0001-9798-8032
Stephen W WhiteDepartment of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0001-8188-5944
Andrew M DavidoffDepartment of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0001-7900-2794
Jun YangDepartment of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0002-4233-3220
St. Jude Children's Research Hospital · USNationwide Children's Hospital · USHebei Medical University · CNUniversity of Washington · USUniversity of Wisconsin–Madison · US
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Shondra Michelle Miller · 1985 to 2026
$166.9MShared Resources Core 2: Quantitative Proteomics CoreP01CA196539 · NCI · ROCKEFELLER UNIVERSITY · PI MAJEWSKI, JACEK · 2015 to 2024
$17.6MMetabolic programming in TH17 cell differentiationR01AI114581 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI WANG, RUONING · 2015 to 2025
$3.6MModulation of asparagine bioavailability and stress response signaling to enhance T cell robustness and maximize immunotherapyR01CA247941 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI WANG, RUONING · 2021 to 2025
$2.4MDecipher and target GABA metabolism and GABA receptor-mediated signaling in autoimmune diseasesR01AI175004 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Ruoning Wang · 2023 to 2026
$2.0MDevelopment of small molecules to target KDM4BR01CA229739 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHEN, TAOSHENG, DAVIDOFF, ANDREW M · 2018 to 2021
$1.6MWT1 as an oncogene and therapeutic target in anaplastic Wilms tumorK08CA255569 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI MURPHY, ANDREW J · 2021 to 2025
$1.2MOncogenic fusion gene FAX-FKHR in driving metabolic reprogramming in alveolar rhabdomyosarcomaR21CA227926 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI CHANDLER, DAWN S, WANG, RUONING · 2019 to 2020
$364kThe role of JMJD6 in MYC-mediated neuroblastomaR03CA212802 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI YANG, JUN · 2017 to 2018
$180kNCI NIH HHS K08 CA255569NCI NIH HHS P01 CA196539NCI NIH HHS P30 CA021765NCI NIH HHS R01 CA229739NCI NIH HHS R01 CA247941NCI NIH HHS R03 CA212802NCI NIH HHS R21 CA227926NIAID NIH HHS R01 AI114581NIAID NIH HHS R01 AI175004
Abstract
Chimeric transcription factors drive lineage-specific oncogenesis but are notoriously difficult to target. Alveolar rhabdomyosarcoma (RMS) is an aggressive childhood soft tissue sarcoma transformed by the pathognomonic Paired Box 3-Forkhead Box O1 (PAX3-FOXO1) fusion protein, which governs a core regulatory circuitry transcription factor network. Here, we show that the histone lysine demethylase 4B (KDM4B) is a therapeutic vulnerability for PAX3-FOXO1
Indexed as
RhabdomyosarcomaRhabdomyosarcoma, AlveolarCarcinogenesisCell Line, TumorChildForkhead Box Protein O1Forkhead Transcription FactorsGene Expression Regulation, NeoplasticHumansJumonji Domain-Containing Histone DemethylasesOncogene Proteins, FusionPaired Box Transcription FactorsPAX3 Transcription FactorForkhead Box Protein O1Forkhead Transcription FactorsFOXO1 protein, humanJumonji Domain-Containing Histone DemethylasesKDM4B protein, humanOncogene Proteins, FusionPaired Box Transcription FactorsPAX3 protein, humanPAX3 Transcription Factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.