ArticleScience signaling2022
A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells.
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Article in Science signaling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
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Who cites it
27 citing papers in PubMed, 30 citations in OpenAlex.
- Tuning T cells to give cancer the blues.Nature immunology · 2026Article
- RAS P21 Protein Activator 3 finetunes Type I immunity by limiting HCK-mediated STAT4 phosphorylation.Nature communications · 2026Article
- A renaissance in targeting the PI3K/AKT/mTOR pathway.Nature reviews. Drug discovery · 2026Review
- CLEC2B-KLRB1 axis acts as an immune checkpoint, governing the exhaustion of CD8Journal for immunotherapy of cancer · 2026Article
- A Rasa3-Gαi signaling axis orchestrates B lymphocyte trafficking into and through lymphoid organs.Cell reports · 2026Article
- A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation.The Journal of experimental medicine · 2026Article
- KLF2 overrides the resident memory CD8 T cell differentiation program, in opposition to KLF3.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- High-throughput screening to engineer optimal T cell therapies: current knowledge and future prospects.Frontiers in oncology · 2026Review
- Ras protein activator-like 3 is a key Ras GTPase-activating protein that protects the survival and anti-tumor activity of CD8Frontiers in immunology · 2026Article
- Optimal CXCR5 expression during Tfh maturation involves the Bhlhe40-Pou2af1 axis.Cell reports · 2025Article
- Article
- RNAi library screening reveals Gβ1, Casein Kinase 2 and ICAP-1 as novel regulators of LFA-1-mediated T cell polarity and migration.Immunology and cell biology · 2025Article
- Integrin alpha L: structure, cellular functions, and emerging role in human diseases.Frontiers in immunology · 2025Review
- Striosomes control dopamine via dual pathways paralleling canonical basal ganglia circuits.Current biology : CB · 2024Article
- High-throughput screening for optimizing adoptive T cell therapies.Experimental hematology & oncology · 2024Review
- Striosomes Target Nigral Dopamine-Containing Neurons via Direct-D1 and Indirect-D2 Pathways Paralleling Classic Direct-Indirect Basal Ganglia Systems.bioRxiv : the preprint server for biology · 2024Article
- Functional CRISPR screens in T cells reveal new opportunities for cancer immunotherapies.Molecular cancer · 2024Review
- Evidence that inositol 1,4,5-trisphosphate 3-kinase and inositol 1,3,4,5-tetrakisphosphate are negative regulators of platelet function.Research and practice in thrombosis and haemostasis · 2024Article
- Tumor-Infiltrating Normal B Cells Revealed by Immunoglobulin Repertoire Clonotype Analysis Are Highly Prognostic and Crucial for Antitumor Immune Responses in DLBCL.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023Article
- Mind the GAP: RASA2 and RASA3 GTPase-activating proteins as gatekeepers of T cell activation and adhesion.Trends in immunology · 2023Review
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 3 countries.
Kristoffer H JohansenCell Signaling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-7711-9451
Dominic P GolecCell Signaling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-2741-3302
Bonnie HuangCell Signaling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-5931-6075
Chung ParkB-Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-7819-5333
Julie H ThomsenDepartment of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.ORCID 0000-0002-0091-3614
Silvia PreiteCell Signaling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Jennifer L CannonsCell Signaling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Fabien GarçonDepartment of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.
Edward C SchromLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-1793-6433
Christina J F CourrègesDepartment of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.ORCID 0000-0003-0203-8486
Tibor Z VeresLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-6980-8900
James HarrisonCardiovascular Division, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0003-4960-5062
Meritxell NusCardiovascular Division, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0002-6378-8910
James D PhelanLymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Wolfgang BergmeierBiochemistry and Biophysics, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0002-1211-8861
John H KehrlB-Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Klaus OkkenhaugDepartment of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.ORCID 0000-0002-9432-4051
Pamela L SchwartzbergCell Signaling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-6318-9187
National Institutes of Health · USUniversity of Cambridge · GBNational Institute of Allergy and Infectious Diseases · USUniversity of North Carolina at Chapel Hill · US
Funding
Genetic and Biochemical Approaches to Tyrosine Kinase and Lymphocyte SignalingZIAAI001240 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SCHWARTZBERG, PAMELA · 2019 to 2025
$18.8MSignal Transduction In B Lymphocytes: Identification Of Key Signaling MoleculesZIAAI000739 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KEHRL, JOHN H · 2009 to 2025
$17.8MControl Of G Protein Signaling: Role Of The RGSsZIAAI000738 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KEHRL, JOHN H · 2009 to 2025
$15.9MSmall GTPases in the biology of platelets and megakaryocytesR35HL144976 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BERGMEIER, WOLFGANG · 2019 to 2025
$5.4MBiotechnology and Biological Sciences Research Council BB/T007826/1British Heart Foundation FS/20/23/34784NHLBI NIH HHS R35 HL144976Wellcome TrustWellcome Trust 200925/Z/16/Z
Abstract
The integrin lymphocyte function-associated antigen 1 (LFA-1) helps to coordinate the migration, adhesion, and activation of T cells through interactions with intercellular adhesion molecule 1 (ICAM-1) and ICAM-2. LFA-1 is activated during the engagement of chemokine receptors and the T cell receptor (TCR) through inside-out signaling, a process that is partially mediated by phosphoinositide 3-kinase (PI3K) and its product phosphatidylinositol 3,4,5-trisphosphate (PIP
Indexed as
Lymphocyte Function-Associated Antigen-1Phosphatidylinositol 3-KinasesAnimalsAntigens, CDCell AdhesionCell Adhesion MoleculesClustered Regularly Interspaced Short Palindromic RepeatsGTPase-Activating ProteinsIntercellular Adhesion Molecule-1MicePhosphatidylinositol 3-KinaseT-LymphocytesAntigens, CDCell Adhesion MoleculesGTPase-Activating ProteinsICAM-2 protein, mouseIntercellular Adhesion Molecule-1Lymphocyte Function-Associated Antigen-1Phosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesRASA3 protein, mouse
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