ArticleScience (New York, N.Y.)2022
Conformational selection guides β-arrestin recruitment at a biased G protein-coupled receptor.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
What it found
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Systematic identification of p11 as a signaling modulator across the GPCRome.Science advances · 2026Article
- Structural basis of active state coupling of metabotropic glutamate receptor 8 to beta-arrestins.Nature communications · 2026Article
- Nuclear magnetic resonance of membrane proteins-Advances and opportunities.Current opinion in structural biology · 2026Review
- Nanobodies unlock new mechanisms to target G protein-coupled receptors.Molecular pharmacology · 2026Review
- Location-biased β-arrestin conformations direct GPCR signaling.Science signaling · 2026Article
- Binding pose depth modulates photoswitchable ligands' efficacy at the 5-HTCommunications chemistry · 2026Article
- Atypical GPCR Activation Resolved by Nanobody Engineering.bioRxiv : the preprint server for biology · 2026Article
- Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies.Nature communications · 2025Article
- Extracellular nanobody screening using conformationally stable GPCR variants.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Biased Agonists of the Type 1 Angiotensin II Receptor Promote Distinct Subcellular β-Arrestin Conformations.Biochemistry · 2025Article
- Progress toward new function and design of extracellular G protein-coupled receptor nanobodies.Molecular pharmacology · 2025Review
- Design, Synthesis, and In Vitro Characterization of a Tryptamine-Based Visible-Light Photoswitchable 5-HTJournal of medicinal chemistry · 2025Article
- Encoding and decoding selectivity and promiscuity in the human chemokine-GPCR interaction network.Cell · 2025Article
- Article
- Temporal complexity of LVV-hemorphin-7 allosterism at the angiotensin II type 1 receptor assessed using entropy-based approaches.Computational and structural biotechnology journal · 2025Article
- Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies.bioRxiv : the preprint server for biology · 2024Article
- Atypical chemokine receptors in the immune system.Nature reviews. Immunology · 2024Review
- The Impact of Nanobodies on G Protein-Coupled Receptor Structural Biology and Their Potential as Therapeutic Agents.Molecular pharmacology · 2024Review
- Conformational dynamics underlying atypical chemokine receptor 3 activation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Structural basis for selectivity and antagonism in extracellular GPCR-nanobodies.Nature communications · 2024Article
Corrections and comments
- Commented on by
Authors and funding
17 authors at 5 institutions in 4 countries.
Andrew B Kleist *Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-4954-010X
Shawn Jenjak *Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-2142-334X
Andrija SenteMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.ORCID 0000-0001-5407-9138
Lauren J LaskowskiDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0003-3979-7507
Martyna SzpakowskaImmuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health (LIH), L-4354 Esch-sur-Alzette, Luxembourg.ORCID 0000-0002-5659-8377
Maggie M CalkinsDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Emilie I AndersonDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Lisa M McNallyDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Raimond HeukersAmsterdam Institute for Molecular and Life Sciences, Division of Medicinal Chemistry, Faculty of Sciences, Vrije Universiteit, 1081 HZ Amsterdam, Netherlands.ORCID 0000-0003-4498-7751
Vladimir BobkovAmsterdam Institute for Molecular and Life Sciences, Division of Medicinal Chemistry, Faculty of Sciences, Vrije Universiteit, 1081 HZ Amsterdam, Netherlands.ORCID 0000-0002-5414-8188
Francis C PetersonDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0001-9890-4224
Monica A ThomasDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0003-2513-3371
Andy ChevignéImmuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health (LIH), L-4354 Esch-sur-Alzette, Luxembourg.ORCID 0000-0003-4768-6743
Martine J SmitAmsterdam Institute for Molecular and Life Sciences, Division of Medicinal Chemistry, Faculty of Sciences, Vrije Universiteit, 1081 HZ Amsterdam, Netherlands.
John D McCorvyDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0001-7555-9413
M Madan BabuDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0003-0556-6196
Brian F VolkmanDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-6681-5179
Medical College of Wisconsin · USVrije Universiteit Amsterdam · NLLuxembourg Institute of Health · LUMRC Laboratory of Molecular Biology · GBSt. Jude Children's Research Hospital · US
Funding
Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7MStructural Basis for Chemokine FunctionR01AI058072 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI VOLKMAN, BRIAN F · 2004 to 2019
$4.1MMolecular Mechanisms of G protein-coupled Receptor Biased SignalingR35GM133421 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI John D McCorvy · 2019 to 2026
$3.3MStructural Basis for Chemokine FunctionR37AI058072 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI Brian F Volkman · 2020 to 2026
$2.8M800 MHz NMR Spectrometer for Southeast WisconsinS10OD025000 · OD · MEDICAL COLLEGE OF WISCONSIN · PI VOLKMAN, BRIAN F · 2019 to 2019
$2.0MStructural basis of chemokine receptor signaling in tumor progressionF30CA196040 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI KLEIST, ANDREW B · 2016 to 2020
$233kValidating CCL28 as a Target for Novel Asthma Therapies using NMR SpectroscopyF30HL134253 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI THOMAS, MONICA A · 2017 to 2019
$140kMedical Research Council MC_UP_1201/15NCI NIH HHS F30 CA196040NHLBI NIH HHS F30 HL134253NIAID NIH HHS R01 AI058072NIAID NIH HHS R37 AI058072NIGMS NIH HHS R35 GM133421NIGMS NIH HHS T32 GM080202NIH HHS S10 OD025000
Abstract
G protein-coupled receptors (GPCRs) recruit β-arrestins to coordinate diverse cellular processes, but the structural dynamics driving this process are poorly understood. Atypical chemokine receptors (ACKRs) are intrinsically biased GPCRs that engage β-arrestins but not G proteins, making them a model system for investigating the structural basis of β-arrestin recruitment. Here, we performed nuclear magnetic resonance (NMR) experiments on
Indexed as
beta-ArrestinsReceptors, CXCRAllosteric RegulationLigandsMagnetic Resonance SpectroscopyMutationProtein BindingProtein ConformationACKR3 protein, humanbeta-ArrestinsLigandsReceptors, CXCR
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.