ArticleScience advances2022
Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Engineering Extended Release Profiles for Biologic Formulations via Chemical Cross-Linking of Poloxamer 407 Hydrogels.ACS omega · 2025Article
- Development of a single-dose Q fever vaccine with an injectable nanoparticle-loaded hydrogel: effect of sustained co-delivery of antigen and adjuvant.Drug delivery · 2025Article
- Infusion of neutralization into Lassa vaccine design.Trends in immunology · 2025Review
- Core-shell microcapsules compatible with routine injection enable prime/boost immunization against malaria with a single shot.Science translational medicine · 2025Article
- Programmable Cargo Release from Jet-Printed Microgel Particles via an In Situ Ionic Exchange Method.Chem & bio engineering · 2025Article
- SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials.Journal of nanobiotechnology · 2025Review
- Article
- TOWARD CONTROLLED-RELEASE DRUG DELIVERY MICROCARRIERS ENABLED BY DIRECT LASER WRITING 3D PRINTING.Proceedings. IEEE International Conference on Micro Electro Mechanical Systems · 2024Article
- A spatiotemporal computational model of focused ultrasound heat-induced nano-sized drug delivery system in solid tumors.Drug delivery · 2023Article
- A comparative study of freeze-drying heat transfer in polymeric vials and glass vials.Scientific reports · 2023Article
- Advanced subunit vaccine delivery technologies: From vaccine cascade obstacles to design strategies.Acta pharmaceutica Sinica. B · 2023Review
- A Scalable Platform for Fabricating Biodegradable Microparticles with Pulsatile Drug Release.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Iterative hypothesis testing in HIV vaccine research: moving towards success.Journal of the International AIDS Society · 2023Article
- Single-Administration Long-Acting Microarray Patch with Ultrahigh Loading Capacity and Multiple Releases of Thermally Stable Antibodies.Molecular pharmaceutics · 2023Article
- The Future of Drug Delivery.Chemistry of materials : a publication of the American Chemical Society · 2023Article
- The landscape of mRNA nanomedicine.Nature medicine · 2022Review
- A Single-Administration Microneedle Skin Patch for Multi-Burst Release of Vaccine against SARS-CoV-2.Advanced materials technologies · 2022Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Next-generation therapeutics require advanced drug delivery platforms with precise control over morphology and release kinetics. A recently developed microfabrication technique enables fabrication of a new class of injectable microparticles with a hollow core-shell structure that displays pulsatile release kinetics, providing such capabilities. Here, we study this technology and the resulting core-shell microstructures. We demonstrated that pulsatile release is governed by a sudden increase in porosity of the polymeric matrix, leading to the formation of a porous path connecting the core to the environment. Moreover, the release kinetics within the range studied remained primarily independent of the particle geometry but highly dependent on its composition. A qualitative technique was developed to study the pattern of pH evolution in the particles. A computational model successfully modeled deformations, indicating sudden expansion of the particle before onset of release. Results of this study contribute to the understanding and design of advanced drug delivery systems.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.