ReviewBrain : a journal of neurology2022
Understanding the multidimensional cognitive deficits of logopenic variant primary progressive aphasia.
Review in Brain : a journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
- Beyond language: A structured profile of number processing impairment in logopenic primary progressive aphasia.Journal of Alzheimer's disease : JAD · 2026Article
- A Comprehensive Review on the Microbial Signatures and Metabolic Mechanisms Underlying the Gut-Alzheimer's Disease Axis.Molecular neurobiology · 2026Review
- Ultra-rare variants in LAMA2 are risk factors for frontotemporal dementia and motor neuron disease.Human molecular genetics · 2026Article
- Empathy in primary progressive aphasia: Neural signatures and longitudinal trajectories.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Multidimensional cognitive deficits in the typical and atypical variants of Alzheimer's disease.Alzheimer's research & therapy · 2025Article
- Disentangling phonology from phonological short-term memory in Alzheimer's disease phenotypes.Alzheimer's research & therapy · 2025Article
- Application of machine learning and temporal response function modeling of EEG data for differential diagnosis in primary progressive aphasia.Scientific reports · 2025Article
- Connected Speech Alterations and Progression in Patients With Primary Progressive Aphasia Variants.Neurology · 2025Article
- Screening for Executive Impairment in Patients with Frontotemporal Dementia: Evidence from the Greek Version of the Frontier Executive Screen.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- Data-driven neuroanatomical subtypes of primary progressive aphasia.Brain : a journal of neurology · 2025Article
- The graded multidimensional geometry of phenotypic variation and progression in neurodegenerative syndromes.Brain : a journal of neurology · 2025Article
- Gut-brain axis and brain health: modulating neuroinflammation, cognitive decline, and neurodegeneration.3 Biotech · 2025Review
- Effects of Cognitive Demand and Imaginability on Semantic Cognition in Patients with Primary Progressive Aphasia.Current Alzheimer research · 2025Article
- Language assessment in primary progressive aphasia: Which components should be tested?PloS one · 2025Article
- Impaired semantic control in the logopenic variant of primary progressive aphasia.Brain communications · 2025Article
- Primary Progressive Aphasia in Italian and English: A Cross-Linguistic Cohort Study.Neurology · 2024Observational
- Symptom-based staging for logopenic variant primary progressive aphasia.European journal of neurology · 2024Article
- Primary progressive aphasia: six questions in search of an answer.Journal of neurology · 2024Review
- Assessing processing speed and its neural correlates in the three variants of primary progressive aphasia with a non-verbal tablet-based task.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Symptom-led staging for semantic and non-fluent/agrammatic variants of primary progressive aphasia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
The logopenic variant of primary progressive aphasia is characterized by early deficits in language production and phonological short-term memory, attributed to left-lateralized temporoparietal, inferior parietal and posterior temporal neurodegeneration. Despite patients primarily complaining of language difficulties, emerging evidence points to performance deficits in non-linguistic domains. Temporoparietal cortex, and functional brain networks anchored to this region, are implicated as putative neural substrates of non-linguistic cognitive deficits in logopenic variant primary progressive aphasia, suggesting that degeneration of a shared set of brain regions may result in co-occurring linguistic and non-linguistic dysfunction early in the disease course. Here, we provide a Review aimed at broadening the understanding of logopenic variant primary progressive aphasia beyond the lens of an exclusive language disorder. By considering behavioural and neuroimaging research on non-linguistic dysfunction in logopenic variant primary progressive aphasia, we propose that a significant portion of multidimensional cognitive features can be explained by degeneration of temporal/inferior parietal cortices and connected regions. Drawing on insights from normative cognitive neuroscience, we propose that these regions underpin a combination of domain-general and domain-selective cognitive processes, whose disruption results in multifaceted cognitive deficits including aphasia. This account explains the common emergence of linguistic and non-linguistic cognitive difficulties in logopenic variant primary progressive aphasia, and predicts phenotypic diversification associated with progression of pathology in posterior neocortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.