Evidence map›Paper›PMID 35857473›Full record

ArticleScience advances2022

Battery-free, tuning circuit-inspired wireless sensor systems for detection of multiple biomarkers in bodily fluids.

Tzu-Li Liu, Yan Dong, Shulin Chen, Jie Zhou, Zhenqiang Ma, Jinghua Li

Abstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. A wireless self-decoupling scheme for multimodal sensing.Microsystems & nanoengineering · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Skin-Interfaced Bifluidic Paper-Based Device for Quantitative Sweat Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tzu-Li LiuDepartment of Materials Science and Engineering, The Ohio State University, Columbus, OH 43220, USA.ORCID 0000-0001-6595-8517
Yan DongDepartment of Materials Science and Engineering, The Ohio State University, Columbus, OH 43220, USA.ORCID 0000-0003-4606-6518
Shulin ChenDepartment of Materials Science and Engineering, The Ohio State University, Columbus, OH 43220, USA.ORCID 0000-0002-0280-1536
Jie ZhouDepartment of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0003-1393-3662
Zhenqiang MaDepartment of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0001-9214-1342
Jinghua LiDepartment of Materials Science and Engineering, The Ohio State University, Columbus, OH 43220, USA.ORCID 0000-0001-8985-566X

Funding

The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUL1TR002733 · NCATS · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2018 to 2022
$28.9M
NCATS NIH HHS UL1 TR002733
6 · The paper itself

Abstract

Tracking the concentration of biomarkers in biofluids can provide crucial information about health status. However, the complexity and nonideal form factors of conventional digital wireless schemes impose challenges in realizing biointegrated, lightweight, and miniaturized sensors. Inspired by the working principle of tuning circuits in radio frequency electronics, this study reports a class of battery-free wireless biochemical sensors: In a resonance circuit, the coupling between a sensing interface and an inductor-capacitor oscillator through a pair of varactor diodes converts a change in electric potential into a modulation in capacitance, resulting in a quantifiable shift of the resonance circuit. Proper design of sensing interfaces with biorecognition elements enables the detection of various biomarkers, including ions, neurotransmitters, and metabolites. Demonstrations of "smart accessories" and miniaturized probes suggest the broad utility of this circuit model. The design concepts and sensing strategies provide a realistic pathway to building biointegrated electronics for wireless biochemical sensing.

Identifiers

PMID35857473
PMCPMC9258955

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.