ArticleScience advances2022
Progerin modulates the IGF-1R/Akt signaling involved in aging.
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In one paragraph
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Age-related IGF-1 decline permits a redox-sensitive transcriptional shift that directs hematopoiesis toward a CCR2Redox biology · 2026Article
- An intelligent nano-engineered PLGA@IGF-1 hydrogel for programmed immune modulation and tendon regeneration via IGF-1R/AKT signaling.Journal of nanobiotechnology · 2026Article
- Removing therapy-induced senescent cancer cells targets and potentiates the response of pancreatic cancer cells toward PARP inhibitors as maintenance therapy.Apoptosis : an international journal on programmed cell death · 2026Article
- An innovative in vitro system unveils IGF1R signaling regulating Merkel cell generation.Stem cell reports · 2026Article
- A study on the nutritional status and body composition of children with Hutchinson-Gilford progeria syndrome.Orphanet journal of rare diseases · 2026Article
- Article
- Cancer-cell-secreted DDAH1 induces TGF-β1/Smad3 signaling pathway to promote fibrosis and aging in lung.Nature aging · 2026Article
- Precise progerin targeting using RfxCas13d: A therapeutic avenue for Hutchinson-Gilford progeria syndrome.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- The accumulation of progerin underlies the loss of aortic smooth muscle cells in Hutchinson-Gilford progeria syndrome.Cell death & disease · 2025Article
- Regulation and function of insulin and insulin-like growth factor receptor signalling.Nature reviews. Molecular cell biology · 2025Review
- SET8 inhibition preserves PTEN to attenuate kidney cell apoptosis in cisplatin nephrotoxicity.Cell death & disease · 2025Article
- Angiopoietin-2: A Therapeutic Target for Vascular Protection in Hutchinson-Gilford Progeria Syndrome.International journal of molecular sciences · 2024Review
- PMEcotoxicology and environmental safety · 2024Article
- Silencing circATXN1 in Aging Nucleus Pulposus Cell Alleviates Intervertebral Disc Degeneration via Correcting Progerin Mislocalization.Research (Washington, D.C.) · 2024Article
- Astragalus polysaccharide ameliorates insulin resistance in HepG2 cells through activating the STAT5/IGF-1 pathway.Immunity, inflammation and disease · 2023Article
- Downregulation of KLF10 contributes to the regeneration of survived renal tubular cells in cisplatin-induced acute kidney injury via ZBTB7A-KLF10-PTEN axis.Cell death discovery · 2023Article
- Review
- LINC00452 overexpression reverses oxLDL-induced injury of human umbilical vein endothelial cells (HUVECs)Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Bo JiangCollege of Basic Medical Sciences, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.ORCID 0000-0003-1261-7705
Xuan WuCollege of Basic Medical Sciences, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.
Fang MengCollege of Basic Medical Sciences, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.
Limiao SiCollege of Basic Medical Sciences, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.
Sunrun CaoCollege of Basic Medical Sciences, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.
Yuqing DongDepartment of Plastic Surgery, The First Hospital of China Medical University, Shenyang, China.
Huayi SunCollege of Basic Medical Sciences, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.
Mengzhu LvDepartment of Plastic Surgery, The First Hospital of China Medical University, Shenyang, China.
Hongde XuCollege of Basic Medical Sciences, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.ORCID 0000-0002-8026-2443
Ning BaiCollege of Basic Medical Sciences, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.ORCID 0000-0001-9873-9070
Qiqiang GuoCollege of Basic Medical Sciences, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.
Xiaoyu SongCollege of Basic Medical Sciences, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.ORCID 0000-0002-6606-327X
Yang YuInstitute of Health Sciences, China Medical University, Shenyang, China.
Wendong GuoCollege of Basic Medical Sciences, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.
Fei YiCollege of Basic Medical Sciences, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.ORCID 0000-0002-4377-6285
Tingting ZhouCollege of Basic Medical Sciences, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.ORCID 0000-0002-5760-736X
Xiaoman LiCollege of Basic Medical Sciences, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.ORCID 0000-0002-6011-382X
Yanling FengCollege of Basic Medical Sciences, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.
Zhuo WangCollege of Basic Medical Sciences, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.
Dan ZhangDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Yi GuanCollege of Basic Medical Sciences, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.ORCID 0000-0002-1944-1610
Mengtao MaCollege of Basic Medical Sciences, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.
Jingwei LiuCollege of Basic Medical Sciences, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.
Xining LiDepartment of Pathology, School of Medicine, Huzhou University, Zhejiang Province, China.
Weidong ZhaoDepartment of Developmental Cell Biology, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.ORCID 0000-0003-0029-4400
Baohua LiuCenter for Anti-Aging and Regenerative Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China.ORCID 0000-0002-1599-8059
Toren FinkelAging Institute, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID 0000-0002-0726-3546
Liu CaoCollege of Basic Medical Sciences, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.ORCID 0000-0001-6471-1993
Funding
Vascular autophagy as a mediator of vascular aging and homeostasisR01HL142663 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FINKEL, TOREN · 2018 to 2021
$2.2MNHLBI NIH HHS R01 HL142663
Abstract
Progerin, a product of
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.