Evidence map›Paper›PMID 35857281›Full record

ArticleJournal of applied toxicology : JAT2022

Disruption of vitamin A homeostasis by the biocide tetrakis(hydroxymethyl) phosphonium sulphate in pregnant rabbits.

Natalia Estrada-Ortiz, Viktoriia Starokozhko, Hidde van Steenwijk, Cor van der Heide, Hjalmar Permentier, Lisanne van Heemskerk, Grietje Harmanna Prins, Janette Heegsma, Klaas Nico Faber, Steffi Bressers and 6 more

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In one paragraph

Article in Journal of applied toxicology : JAT, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 4 countries.

Natalia Estrada-OrtizGroningen Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, The Netherlands.
Viktoriia StarokozhkoGroningen Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, The Netherlands.
Hidde van SteenwijkGroningen Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, The Netherlands.
Cor van der HeideGroningen Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, The Netherlands.
Hjalmar PermentierGroningen Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, The Netherlands.
Lisanne van HeemskerkGroningen Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, The Netherlands.
Grietje Harmanna PrinsGroningen Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, The Netherlands.
Janette HeegsmaDepartment of Gastroenterology and Hepatology, University of Groningen, University Medi-cal Center Groningen, Groningen, The Netherlands.
Klaas Nico FaberDepartment of Gastroenterology and Hepatology, University of Groningen, University Medi-cal Center Groningen, Groningen, The Netherlands.
Steffi BressersCharles River Laboratories, 's-Hertogenbosch, The Netherlands.
Guy SteiblenSolvay, Toxicological and Environmental Risk Assessment Unit, Genas, France.
Antoinette de GrootSolvay, Toxicological and Environmental Risk Assessment Unit, Bruxelles, Belgium.
Steve GroomeSolvay, Product Stewardship, Oldbury, UK.
Erik van MiertSolvay, Toxicological and Environmental Risk Assessment Unit, Bruxelles, Belgium.
Geny GroothuisGroningen Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, The Netherlands.
Inge Anne Maria de GraafUniversity Medical Center Groningen, Surgical Research Laboratory, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-0760-8356
University of Groningen · NLUniversity Medical Center Groningen · NLSolvay (Belgium) · BECharles River Laboratories (Netherlands) · NLSolvay (France) · FRSolvay (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The biocide tetrakis(hydroxymethyl)phosphonium sulphate (THPS) and other members of the tetrakis(hydroxymethyl) phosphonium salts (THPX) family are associated with liver toxicity in several mammalian species and teratogenicity in rabbits. Malformations include skeletal changes and abnormalities in eye development and are very similar to those seen with vitamin A deficiency or excess. For this reason, it was hypothesized that teratogenicity of THPS(X) might be attributed to disturbances in retinol availability and/or metabolism as a result of maternal toxicity, for example, either due to insufficient dietary intake by the mothers or due to liver toxicity. Therefore, in the present study, liver toxicity and vitamin A homeostasis were studied in pregnant rabbits that were exposed to 13.8 or 46.0 mg/kg THPS during organogenesis and in precision-cut liver slices of rats and rabbits exposed to 0-70 μM THPS. Results show that in vivo exposure to THPS leads to a marked reduction of food intake, increased plasma concentrations of γ-glutamytransferase, degenerative changes in the liver and to changes in retinoid content in liver and plasma in the rabbits during organogenesis. In addition, THPS, both in vivo and ex vivo, caused a change in expression of proteins related to vitamin A metabolism and transport. Together, these observations could explain the birth defects observed in earlier teratogenicity studies.

Indexed as

DisinfectantsAnimalsFemaleHomeostasisLiverMammalsPregnancyRabbitsRatsSulfatesVitamin ADisinfectantsSulfatesVitamin Acytochrome p45026A1precision-cut liver slicesretinoid binding proteinsretinoidsteratogenicitytetrakis(hydroxymethyl) phosphonium sulphateTHPSVADvitamin A homeostasis

Identifiers

PMID35857281
PMCPMC9804500
OpenAlexW4286001671

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.