Evidence map›Paper›PMID 35857243›Full record

SynthesisCurrent environmental health reports2022

Is Greenness Associated with Dementia? A Systematic Review and Dose-Response Meta-analysis.

Federico Zagnoli, Tommaso Filippini, Marcia P Jimenez, Lauren A Wise, Elizabeth E Hatch, Marco Vinceti

Open access · hybridAbstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Current environmental health reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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  9. Urban greenspace and dementia: Measures, mechanisms, and methodological guidance.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Federico ZagnoliEnvironmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia Medical School, 287 Via Campi, 41125, Modena, Italy.
Tommaso FilippiniEnvironmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia Medical School, 287 Via Campi, 41125, Modena, Italy.ORCID 0000-0003-2100-0344
Marcia P JimenezDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, 02118, USA.ORCID 0000-0001-5240-7898
Lauren A WiseDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, 02118, USA.ORCID 0000-0003-2138-3752
Elizabeth E HatchDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, 02118, USA.ORCID 0000-0001-7901-3928
Marco VincetiEnvironmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia Medical School, 287 Via Campi, 41125, Modena, Italy. marco.vinceti@unimore.it.ORCID 0000-0002-0551-2473
Boston University · USUniversity of Modena and Reggio Emilia · IT

Funding

Neurodegenerative diseases and the role of green space: A deep learning assessmentR00AG066949 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI PESCADOR JIMENEZ, MARCIA IXCHEL · 2022 to 2024
$738k
NIA NIH HHS R00 AG066949
6 · The paper itself

Abstract

purpose of reviewWe assessed the relation between environmental greenness and risk of dementia and cognitive impairment, based on a systematic review and meta-analysis up to March 30, 2022, characterizing whenever possible the shape of the association using dose-response meta-analysis. RECENT

findingsTwelve studies were included in this review, either using normalized difference vegetation index (NDVI) or land use/cover (LU/LC) methodology to assess greenness. Comparing the highest versus lowest exposure categories of greenness assessed using the NDVI (6 studies) or LU/LC (6 studies), we found no association with dementia. Dose-response meta-analysis of the association between greenness measured by LU/LC and dementia, based on only 3 studies, indicated a U-shaped association, but estimates were imprecise. Our systematic review and meta-analysis provided some evidence of a slight inverse association between greenness and dementia at intermediate exposure levels, but not at high levels. Potential methodological limitations, such as exposure misclassification and unmeasured confounding, may have affected the results.

Indexed as

DementiaEnvironmentConservation of Natural ResourcesHumansCognitive impairmentDementiaGreennessGreen spaceLand useNDVI

Identifiers

PMID35857243
PMCPMC9729322
OpenAlexW4285900266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.