ReviewJournal of endocrinological investigation2022
Clinical characteristics and outcomes of pheochromocytoma crisis: a literature review of 200 cases.
Review in Journal of endocrinological investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Japan Endocrine Society Clinical Practice Guideline for the Diagnosis and Management of Pheochromocytoma and Paraganglioma 2025.Endocrine journal · 2026Guideline
- Phaeochromocytoma Crisis Presenting As Inverted Takotsubo Cardiomyopathy in a Young Woman: A Successful Outcome.Cureus · 2026Article
- A 42-Year-Old Woman Presenting With Pheochromocytoma Multisystem Crisis Associated With Bilateral Pheochromocytomas Due to Multiple Endocrine Neoplasia Type 2A.The American journal of case reports · 2026Article
- Cardiogenic shock due to pheochromocytoma-induced catecholamine crisis in a young woman.JCEM case reports · 2026Article
- Prediction of postoperative hypoglycemia in patients with pheochromocytoma resection: a retrospective study.BMC surgery · 2026Article
- Resolution of reverse takotsubo cardiomyopathy secondary to presumed pheochromocytoma with intralesional hemorrhage.JCEM case reports · 2026Article
- Metoclopramide-Induced Pheochromocytoma Crisis: A Case Report and Literature Review.Clinical case reports · 2026Article
- Pheochromocytoma presenting with vomiting and heart failure: A case report.World journal of cardiology · 2025Article
- Intracystic catecholamine variations in cystic pheochromocytoma.Journal of endocrinological investigation · 2025Article
- Approach to the Management of Gastrointestinal Manifestations in Patients With Phaeochromocytoma and Paraganglioma.Clinical endocrinology · 2025Article
- Pheochromocytoma Multisystem Crisis Requiring Temporary Mechanical Circulatory Support: A Narrative Review.Journal of clinical medicine · 2025Review
- Surgical anesthesia in a patient with a pheochromocytoma crisis supported by ECMO: a case report.Journal of cardiothoracic surgery · 2024Article
- Unexpected pheochromocytoma leading to cardiac arrest during the perioperative period: a case report and literature review.BMC anesthesiology · 2024Review
- Article
- The role of the adrenalectomy in the management of pheochromocytoma: the experience of a Portuguese referral center.Endocrine · 2024Article
- Unveiling Pheochromocytoma: A Puzzling Prelude of Nausea, Vomiting, and Abdominal Pain.The American journal of case reports · 2024Article
- Cardiogenic shock in phaeochromocytoma multisystem crisis: a case report.European heart journal. Case reports · 2024Article
- In-Hospital Adverse Events of Pheochromocytoma-Induced Takotsubo Syndrome: A Literature Review and Cluster Analysis of 172 Cases.Reviews in cardiovascular medicine · 2024Article
- Metastatic disease and major adverse cardiovascular events preceding diagnosis are the main determinants of disease-specific survival of pheochromocytoma/paraganglioma: long-term follow-up of 303 patients.Frontiers in endocrinology · 2024Article
- A case report on pheochromocytoma mimicking as fulminant myocarditis-a diagnostic challenge.Frontiers in cardiovascular medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePheochromocytoma crisis is a life-threatening endocrine emergency that requires prompt diagnosis and treatment. Because of its rarity, sudden onset, and lack of internationally uniform and validated diagnostic criteria, pheochromocytoma crisis remains to be fully clarified. Therefore, we aimed to describe the clinical characteristics and outcomes of pheochromocytoma crisis through a literature review.
methodsWe performed a systematic literature search of PubMed/MEDLINE database, Igaku-Chuo-Zasshi (Japanese database), and Google Scholar to identify case reports of pheochromocytoma crisis published until February 5, 2021. Information was extracted and analyzed from the literature that reported adequate individual patient data of pheochromocytoma crisis in English or Japanese. Cases were also termed as pheochromocytoma multisystem crisis (PMC) if patients had signs of hyperthermia, multiple organ failure, encephalopathy, and labile blood pressure.
resultsIn the 200 cases of pheochromocytoma crisis identified from 187 articles, the mean patient age was 43.8 ± 15.5 years. The most common symptom was headache (39.5%). The heart was the most commonly damaged organ resulting from a complication of a pheochromocytoma crisis (99.0%), followed by the lungs (44.0%) and the kidney (21.5%). PMC accounted for 19.0% of all pheochromocytoma crisis cases. After excluding 12 cases with unknown survival statuses, the mortality rate was 13.8% (26/188 cases). Multivariable logistic regression analysis revealed that nausea and vomiting were significantly associated with a higher mortality rate.
conclusionPheochromocytoma can present with different symptomatology, affecting different organ systems. Clinicians should be aware that patients with nausea or vomiting are at a higher risk of death because of pheochromocytoma crisis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.