Evidence map›Paper›PMID 35857175›Full record

ArticleMolecular biology reports2022

The CRISPR-Cas system as a tool for diagnosing and treating infectious diseases.

Juan Lou, Bin Wang, Junwei Li, Peng Ni, Yuefei Jin, Shuaiyin Chen, Yuanlin Xi, Rongguang Zhang, Guangcai Duan

Open access · bronzeAbstract read
In one paragraph

Article in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Article
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  6. PlasmaInfectious diseases (London, England) · 2025
    Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. MultigeneThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2025
    Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Challenges in Direct Detection of Flaviviruses: A Review.Pathogens (Basel, Switzerland) · 2023
    Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Juan LouDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China.
Bin WangDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China.
Junwei LiDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China.
Peng NiDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China.
Yuefei JinDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China.
Shuaiyin ChenDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China.
Yuanlin XiDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China.
Rongguang ZhangDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China. zrg@zzu.edu.cn.ORCID http://orcid.org/0000-0001-9961-2434
Guangcai DuanDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China.
Zhengzhou University · CN

Funding

81773495 81773495No.820CXTD438 No.820CXTD438
6 · The paper itself

Abstract

Emerging and relapsing infectious diseases pose a huge health threat to human health and a new challenge to global public health. Rapid, sensitive and simple diagnostic tools are keys to successful management of infectious patients and containment of disease transmission. In recent years, international research on Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-related proteins (Cas) has revolutionized our understanding of biology. The CRISPR-Cas system has the advantages of high specificity, high sensitivity, simple, rapid, low cost, and has begun to be used for molecular diagnosis and treatment of infectious diseases. In this paper, we described the biological principles, application fields and prospects of CRISPR-Cas system in the molecular diagnosis and treatment of infectious diseases, and compared it with existing molecular diagnosis methods, the advantages and disadvantages were summarized.

Indexed as

Communicable DiseasesCRISPR-Cas SystemsHumansApplicationCOVID-19CRISPR-CasInfectious diseases

Identifiers

PMID35857175
PMCPMC9297709
OpenAlexW4286210166

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.