Evidence map›Paper›PMID 35856852›Full record

ArticlePediatric diabetes2022

Higher frequency of cardiovascular autonomic neuropathy in youth with type 2 compared to type 1 diabetes: Role of cardiometabolic risk factors.

Benjamin J Varley, Megan L Gow, Yoon Hi Cho, Paul Benitez-Aguirre, Janine Cusumano, Alison Pryke, Albert Chan, Vallimayil Velayutham, Kim C Donaghue, Maria E Craig

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric diabetes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Article
  5. Article
  6. Article
  7. Complications and Treatment of Early-Onset Type 2 Diabetes.International journal of endocrinology and metabolism · 2023
    Review
  8. Thyroid [IBRO neuroscience reports · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Benjamin J VarleyThe University of Sydney Children's Hospital Westmead Clinical School, Sydney, New South Wales, Australia.ORCID 0000-0002-1191-6108
Megan L GowThe University of Sydney Children's Hospital Westmead Clinical School, Sydney, New South Wales, Australia.ORCID 0000-0002-9574-6248
Yoon Hi ChoThe University of Sydney Children's Hospital Westmead Clinical School, Sydney, New South Wales, Australia.
Paul Benitez-AguirreInstitute of Endocrinology and Diabetes, Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Janine CusumanoInstitute of Endocrinology and Diabetes, Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Alison PrykeInstitute of Endocrinology and Diabetes, Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Albert ChanInstitute of Endocrinology and Diabetes, Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Vallimayil VelayuthamThe University of Sydney Children's Hospital Westmead Clinical School, Sydney, New South Wales, Australia.
Kim C DonaghueThe University of Sydney Children's Hospital Westmead Clinical School, Sydney, New South Wales, Australia.
Maria E CraigThe University of Sydney Children's Hospital Westmead Clinical School, Sydney, New South Wales, Australia.ORCID 0000-0001-6004-576X
The University of Sydney · AUChildren's Hospital at Westmead · AUCamden and Campbelltown Hospitals · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveCardiovascular autonomic neuropathy (CAN) is an overlooked but common and serious diabetes complication. We examined CAN in youth with diabetes and associations with cardiovascular risk factors. RESEARCH DESIGN AND

methodsThis was a prospective cohort of youth aged <20 years with type 2 or type 1 diabetes (n = 66/1153, median age 15.4/16.5 years, duration 1.7/8.0 years), assessed between 2009 and 2020. CAN was defined as ≥2 abnormal heart rate variability measures across time, geometric, and frequency domains. Obesity was defined as BMI ≥ 95th percentile and severe obesity as ≥120% of 95th percentile. Multivariable generalized estimating equations (GEE) were used to examine putative risk factors for CAN, including diabetes type, obesity, and HbA

resultsAt most recent assessment, youth with type 2 versus type 1 diabetes had median: HbA

conclusionsYouth with type 2 diabetes have a higher frequency of CAN, peripheral nerve abnormality, hypertension, albuminuria and severe obesity despite shorter diabetes duration and younger age. Our findings highlight the importance of targeting modifiable risk factors to prevent cardiovascular disease in youth with diabetes.

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2HypertensionNervous System DiseasesObesity, MorbidAdolescentAlbuminuriaCardiometabolic Risk FactorsHumansProspective StudiesRisk Factorscardiovascular autonomic neuropathycardiovascular diseaseheart rate variabilityobesityyouth

Identifiers

PMID35856852
PMCPMC9805172
OpenAlexW4286001965

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.