Evidence map›Paper›PMID 35856680›Full record

ArticleAntimicrobial agents and chemotherapy2022

Quantitative Imaging Analysis of the Spatial Relationship between Antiretrovirals, Reverse Transcriptase Simian-Human Immunodeficiency Virus RNA, and Fibrosis in the Spleens of Nonhuman Primates.

Aaron S Devanathan, Nicole R White, Yury Desyaterik, Gabriela De la Cruz, Michael Nekorchuk, Margaret Terry, Kathleen Busman-Sahay, Lourdes Adamson, Paul Luciw, Yuri Fedoriw and 3 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Enhancing the Sensitivity of Mass Spectrometry Imaging through Spatial Signal Averaging.Journal of the American Society for Mass Spectrometry · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Aaron S DevanathanUNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA.ORCID 0000-0002-2778-3725
Nicole R WhiteUNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA.
Yury DesyaterikUNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA.
Gabriela De la CruzUniversity of North Carolina at Chapel Hillgrid.10698.36 School of Medicine, Chapel Hill, North Carolina, USA.
Michael NekorchukVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.
Margaret TerryVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.
Kathleen Busman-SahayVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.
Lourdes AdamsonUniversity of California at Davis, Davis, California, USA.
Paul LuciwUniversity of California at Davis, Davis, California, USA.
Yuri FedoriwUniversity of North Carolina at Chapel Hillgrid.10698.36 School of Medicine, Chapel Hill, North Carolina, USA.
Jacob D EstesVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.
Elias P RosenUNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA.ORCID 0000-0001-5531-7281
Angela D M KashubaUNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA.
University of North Carolina Health Care · USChildren's Cancer Therapy Development Institute · USUniversity of North Carolina at Chapel Hill · USUniversity of California, Davis · USOregon National Primate Research Center · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Targeting the MEKK2-ERK5 Signaling Node in Triple Negative Breast CancerU54CA156733 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TROESTER, MELISSA A. · 2010 to 2020
$9.7M
Multi-Species Mechanisms of Drug Bio-distribution in HIV Tissue ReservoirsR01AI111891 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KASHUBA, ANGELA D · 2014 to 2018
$4.3M
Defining Mechanisms of Viral Persistence in Situ at the Single-Cell LevelR01AI149672 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI ESTES, JACOB D · 2020 to 2024
$4.0M
Attenuating Inflammation to Restore GI Tract Integrity and Reduce Viral Reservoirs During cARTR01DK119945 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI ESTES, JACOB D · 2018 to 2022
$3.8M
Novel ISH Approaches to Quantify Replication Competent ReservoirsR01AI143411 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI ESTES, JACOB D · 2019 to 2023
$3.6M
NCI NIH HHS U54 CA156733NIAID NIH HHS P30 AI050410NIAID NIH HHS R01 AI111891NIAID NIH HHS R01 AI143411NIAID NIH HHS R01 AI149672NIDDK NIH HHS R01 DK119945NIH HHS P51 OD011092
6 · The paper itself

Abstract

Although current antiretroviral therapy (ART) has increased life expectancy, a cure for human immunodeficiency virus (HIV) remains elusive due to the persistence of the virus in tissue reservoirs. In the present study, we sought to elucidate the relationship between antiretrovirals (ARVs) and viral expression in the spleen. We performed mass spectrometry imaging (MSI) of 6 different ARVs, RNAscope

Indexed as

HIV InfectionsSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAnimalsAnti-Retroviral AgentsFibrosisHIVHIV Reverse TranscriptaseHumansMacaca mulattaMaravirocRNA, ViralSpleenViral LoadAnti-Retroviral AgentsHIV Reverse TranscriptaseMaravirocRNA, Viralantiretroviralsdrug distributionhuman immunodeficiency virusmass spectrometry imagingspleen

Identifiers

PMID35856680
PMCPMC9380553
OpenAlexW4286001542

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.