Evidence map›Paper›PMID 35856590›Full record

ArticleLab on a chip2022

Bacterial chemotaxis in static gradients quantified in a biopolymer membrane-integrated microfluidic platform.

Piao Hu, Khanh L Ly, Le P H Pham, Alex E Pottash, Kathleen Sheridan, Hsuan-Chen Wu, Chen-Yu Tsao, David Quan, William E Bentley, Gary W Rubloff and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lab on a chip, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Piao HuDepartment of Mechanical Engineering, Catholic University of America, Washington, District of Columbia 20064, USA. luox@cua.edu.
Khanh L LyDepartment of Biomedical Engineering, Catholic University of America, Washington, District of Columbia 20064, USA.ORCID 0000-0002-6868-8994
Le P H PhamDepartment of Mechanical Engineering, Catholic University of America, Washington, District of Columbia 20064, USA. luox@cua.edu.
Alex E PottashFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.ORCID 0000-0003-0423-1335
Kathleen SheridanDepartment of Biomedical Engineering, Catholic University of America, Washington, District of Columbia 20064, USA.
Hsuan-Chen WuInstitute for Bioscience & Biotechnology Research, University of Maryland, College Park, MD 20742, USA.
Chen-Yu TsaoInstitute for Bioscience & Biotechnology Research, University of Maryland, College Park, MD 20742, USA.
David QuanInstitute for Bioscience & Biotechnology Research, University of Maryland, College Park, MD 20742, USA.
William E BentleyFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.ORCID 0000-0002-4855-7866
Gary W RubloffDepartment of Materials Science & Engineering, University of Maryland, College Park, MD 20742, USA.ORCID 0000-0002-1901-3982
Herman O SintimDepartment of Chemistry, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-2280-9359
Xiaolong LuoDepartment of Mechanical Engineering, Catholic University of America, Washington, District of Columbia 20064, USA. luox@cua.edu.ORCID 0000-0002-9939-2766
University of Maryland, College Park · USUniversity of America · USPurdue University West Lafayette · US

Funding

Heterogeneous synthetic microbiome constructed with biopolymer fluitrodesR15GM129766 · NIGMS · CATHOLIC UNIVERSITY OF AMERICA · PI CHOY, JOHN SING, LUO, XIAOLONG · 2018 to 2018
$465k
NIGMS NIH HHS R15 GM129766
6 · The paper itself

Abstract

Chemotaxis is a fundamental bacterial response mechanism to changes in chemical gradients of specific molecules known as chemoattractant or chemorepellent. The advancement of biological platforms for bacterial chemotaxis research is of significant interest for a wide range of biological and environmental studies. Many microfluidic devices have been developed for its study, but challenges still remain that can obscure analysis. For example, cell migration can be compromised by flow-induced shear stress, and bacterial motility can be impaired by nonspecific cell adhesion to microchannels. Also, devices can be complicated, expensive, and hard to assemble. We address these issues with a three-channel microfluidic platform integrated with natural biopolymer membranes that are assembled

Indexed as

ChemotaxisMicrofluidic Analytical TechniquesBiopolymersChemotactic FactorsEscherichia coliMicrofluidicsBiopolymersChemotactic Factors

Identifiers

PMID35856590
PMCPMC9756273
OpenAlexW4285049042

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.