ArticlePain medicine (Malden, Mass.)2022
The Relationship Between Patient Demographic and Clinical Characteristics and Successful Treatment Outcomes After Basivertebral Nerve Radiofrequency Ablation: A Pooled Cohort Study of Three Prospective Clinical Trials.
Article in Pain medicine (Malden, Mass.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Consensus practice guidelines on sacroiliac joint complex pain from a multispecialty, international working group.Pain medicine (Malden, Mass.) · 2025Guideline
- The effectiveness of intradiscal corticosteroid injection for the treatment of chronic discovertebral low back pain: a systematic review.Pain medicine (Malden, Mass.) · 2024Pooled it
- Sustained pain relief across modic subtypes following basivertebral nerve ablation: A real-world study.Interventional pain medicine · 2026Article
- Passive recharge burst spinal cord stimulation for the treatment of refractory nonsurgical low back pain: 24-month results from a prospective randomized controlled trial and predictors of success.North American Spine Society journal · 2026Article
- Vertebrogenic Low Back Pain and Basivertebral Nerve Ablation: A Review of Mechanisms, Imaging-Driven Selection, and Clinical Outcomes.Diagnostics (Basel, Switzerland) · 2026Review
- Early pain-response trajectories after basivertebral nerve ablation and their relationship to 12-month clinical outcomes.Interventional pain medicine · 2026Article
- The effectiveness of basivertebral nerve radiofrequency ablation for the treatment of vertebrogenic low back pain: 1-year results of a prospective real-world cohort study.Pain medicine (Malden, Mass.) · 2026Article
- Patient selection, clinical outcomes, associated healthcare utilization, and cost-effectiveness of basivertebral nerve ablation for the treatment of vertebrogenic low back pain: A narrative review.North American Spine Society journal · 2025Article
- Timing and trajectory of pain and functional outcomes after basivertebral nerve ablation: a prospective cohort study.Interventional pain medicine · 2025Article
- Modic Changes as Biomarkers for Treatment of Chronic Low Back Pain.Biomedicines · 2025Review
- The effectiveness of fluoroscopically guided lumbar facet steroid joint injections: A systematic review.Interventional pain medicine · 2025Review
- Advances in Basivertebral Nerve Ablation for Chronic Low Back Pain: A Narrative Review.Journal of personalized medicine · 2025Review
- Intraosseous basivertebral nerve ablation: A 5-year pooled analysis from three prospective clinical trials.Interventional pain medicine · 2024Article
- Low back pain-related healthcare utilization following intraosseous basivertebral nerve radiofrequency ablation: a pooled analysis from three prospective clinical trials.Pain medicine (Malden, Mass.) · 2024Article
- Basivertebral nerve ablation for the treatment of chronic low back pain in a community practice setting: 6 Months follow-up.North American Spine Society journal · 2023Article
- Intraosseous basivertebral nerve ablation: Pooled long-term outcomes from two prospective clinical trials.Interventional pain medicine · 2023Article
- Pain Location and Exacerbating Activities Associated with Treatment Success Following Basivertebral Nerve Ablation: An Aggregated Cohort Study of Multicenter Prospective Clinical Trial Data.Pain medicine (Malden, Mass.) · 2022Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMultiple studies have demonstrated the safety and effectiveness of basivertebral nerve radiofrequency ablation (BVN RFA) for improving low back pain related to the vertebral endplate. However, the influence of patient demographic and clinical characteristics on treatment outcome is unknown.
designPooled cohort study of three clinical trials of patients with vertebral endplate pain identified by Type 1 and/or Type 2 Modic changes and a correlating presentation of anterior spinal element pain.
settingThirty-three global study centers. SUBJECTS: Patients (n = 296) successfully treated with BVN RFA.
methodsParticipant demographic and clinical characteristics were analyzed with stepwise logistic regression to identify predictors of treatment success. Three definitions of treatment success were defined: 1) ≥50% visual analog scale pain improvement, 2) ≥15-point Oswestry Disability Index (ODI) improvement, and 3) ≥50% visual analog scale or ≥15-point ODI improvement from baseline.
resultsLow back pain of ≥5 years' duration and higher ODI scores at baseline increased the odds of treatment success, whereas baseline opioid use and higher Beck Depression Inventory scores reduced these odds. However, the three regression models demonstrated receiver-operating characteristics of 62-70% areas under the curve, and thus, limited predictive capacity.
conclusionsThis analysis identified no demographic or clinical characteristic that meaningfully increased or reduced the odds of treatment success from BVN RFA. On the basis of these findings and the high response rates from the three analyzed trials, we recommend the use of objective imaging biomarkers (Type 1 and/or 2 Modic changes) and a correlating presentation of anterior spinal element pain to determine optimal candidacy for BVN RFA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.