Evidence map›Paper›PMID 35855978›Full record

ArticleeNeurologicalSci2022

Letters to the editor: Nicotinic acetylcholine receptor ligands as potential targets for managing neuropathic pain induced by diabetic peripheral neuropathy.

Sarah Westlake, Matthew Jones, Krishna D Sharma, Jennifer Yanhua Xie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeurologicalSci, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Novel drugs affecting diabetic peripheral neuropathy.Iranian journal of basic medical sciences · 2024
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sarah WestlakeBasic Sciences Department, New York Institute of Technology College of Osteopathic Medicine at Arkansas State University, Jonesboro, AR, USA.
Matthew JonesBasic Sciences Department, New York Institute of Technology College of Osteopathic Medicine at Arkansas State University, Jonesboro, AR, USA.
Krishna D SharmaDepartment of Biological Sciences and Arkansas Biosciences Institute, Arkansas State University, Jonesboro, AR, USA.
Jennifer Yanhua XieBasic Sciences Department, New York Institute of Technology College of Osteopathic Medicine at Arkansas State University, Jonesboro, AR, USA.
Arkansas State University · US

Funding

Mechanistic Assessment of Osteopathic Manipulation inRelieving Migraine Headache Using a Novel Translational Rodent ModelR15AT011097 · NCCIH · NEW YORK INST OF TECHNOLOGY · PI XIE, YANHUA · 2020 to 2020
$428k
NCCIH NIH HHS R15 AT011097
6 · The paper itself

Abstract

Diabetic peripheral neuropathy (DPN) is a medical condition that is progressively becoming more prevalent. The underlying cause of DPN is still unknown, although there have been several hypothesized mechanisms. There are current pharmaceutical treatments used to manage the pain, but their efficacy is largely unsatisfactory and are often associated with serious adverse effects. This review will explore the evidence of a new potential target for treating DPN, the ligands for nicotinic acetylcholine receptors (nAChRs), specifically α4ꞵ2 agonists and α9α10 antagonists.

Indexed as

AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acidCCL2, C-C motif ligand 2CNS, central nervous systemDiabetic peripheral neuropathyDPN, diabetic peripheral neuropathyDRG, dorsal root gangliaGABA, gamma aminobutyric acidIC50, half-maximal inhibitory concentrationIFN-γ, interferon gammaIL-ꞵ, interleukin-1ꞵnAChR, nicotinic acetylcholine receptorNicotinic acetylcholine receptor ligandsNovel pharmacological treatmentsTNF-α, tumor necrosis factor-alpha

Identifiers

PMID35855978
PMCPMC9287153
OpenAlexW4283788466

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.