Evidence map›Paper›PMID 35855534›Full record

ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2022

The prevalence of obstructive sleep apnea in sarcoidosis and its impact on sleepiness, fatigue, and sleep-associated quality of life: a cross-sectional study with matched controls (the OSASA study).

Maurice Roeder, Noriane A Sievi, Alexandra Schneider, Martin Osswald, Stefan Malesevic, Antonios Kolios, Jakob Nilsson, Malcolm Kohler, Daniel Franzen

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04156789 (Obstructive Sleep Apnoea in Sarcoidosis), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04156789 completednot on this map

Obstructive Sleep Apnoea in Sarcoidosis: A Cross-sectional Observational Study

TypeobservationalSponsorMalcolm KohlerRan2019 to 2021Enrolled149ConditionsSarcoidosis, Obstructive Sleep Apnea, Fatigue, SleepinessArmsHome sleep apnea testing
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Exploring sarcoidosis via nailfold capillaroscopy: A window into the disease's microvascular landscape.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025
    Article
  4. Review
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Maurice RoederDepartment of Pulmonology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Noriane A SieviDepartment of Pulmonology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Alexandra SchneiderDepartment of Pulmonology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Martin OsswaldDepartment of Pulmonology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Stefan MalesevicDepartment of Pulmonology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Antonios KoliosDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Jakob NilssonDepartment of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland.
Malcolm KohlerDepartment of Pulmonology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Daniel FranzenDepartment of Pulmonology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
University Hospital of Zurich · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesPatients with sarcoidosis experience fatigue and excessive daytime sleepiness (EDS). However, the underlying pathomechanism is unclear. Studies suggested undiagnosed obstructive sleep apnea (OSA) to be an important contributor, but reliable data on prevalence and impact of OSA in sarcoidosis are scarce.

methods71 adult patients with sarcoidosis, 1-to-1 matched to 71 adult controls according to sex, age, and body mass index were included. Participants underwent structured interviews (including Epworth Sleepiness Scale [ESS], Fatigue Assessment Scale [FAS], and Functional Outcome of Sleep Questionnaire [FOSQ-30]) and level-3 respiratory polygraphy. OSA was defined as apnea-hypopnea index ≥ 5 events/h. Prevalence of OSA was assessed and possible risk factors for OSA in sarcoidosis were investigated.

resultsMild OSA (AHI ≥ 5 events/h) was prevalent in 32 (45%) sarcoidosis patients vs 22 (31%) controls (

conclusionsThe risk for mild OSA is 2.5-fold higher in sarcoidosis patients compared with matched controls. OSA seems not to be the reason for increased sleepiness or fatigue in sarcoidosis. Risk factors such as body mass index, sex, neck circumference, and NoSAS score can be used to screen for OSA in sarcoidosis patients. CLINICAL

trial registrationRegistry: ClinicalTrials.gov; Name: Obstructive Sleep Apnoea in Sarcoidosis (OSASA); URL: https://clinicaltrials.gov/ct2/history/NCT04156789?V_2=View; Identifier: NCT04156789. CITATION: Roeder M, Sievi NA, Schneider A, et al. The prevalence of obstructive sleep apnea in sarcoidosis and its impact on sleepiness, fatigue, and sleep-associated quality of life: a cross-sectional study with matched controls (the OSASA study).

Indexed as

Disorders of Excessive SomnolenceSarcoidosisSleep Apnea, ObstructiveAdultCross-Sectional StudiesFatigueHumansPrevalenceQuality of LifeSleepSleepinessAHIfatigueobstructive sleep apneasarcoidosis

Identifiers

PMID35855534
PMCPMC9516590
OpenAlexW4286008819

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.