Evidence map›Paper›PMID 35855109›Full record

ArticleRegenerative biomaterials2022

Three-dimensional-printed collagen/chitosan/secretome derived from HUCMSCs scaffolds for efficient neural network reconstruction in canines with traumatic brain injury.

Xiaoyin Liu, Guijun Zhang, Pan Wei, Lin Zhong, Yaxing Chen, Jianyong Zhang, Xuyi Chen, Liangxue Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  12. Secretome as a Tool to Treat Neurological Conditions: Are We Ready?International journal of molecular sciences · 2023
    Review
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  17. The paradigm of stem cell secretome in tissue repair and regeneration: Present and future perspectives.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Xiaoyin LiuDepartment of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, Sichuan, China.
Guijun ZhangDepartment of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, Sichuan, China.
Pan WeiDepartment of Neurosurgery, The First People's Hospital Of Long Quan yi District, Chengdu 610000, Sichuan, China.
Lin ZhongThe First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, Sichuan, China.
Yaxing ChenDepartment of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, Sichuan, China.
Jianyong ZhangDepartment of General Surgery, the Affiliated Hospital of Guizhou Medical University, Guiyang CN 540000, P. R., Guizhou, China.ORCID https://orcid.org/0000-0003-0686-4427
Xuyi ChenTianjin Key Laboratory of Neurotrauma Repair, Pingjin Hospital Brain Center, Characteristic Medical Center of People's Armed Police Forces, Tianjin 300162, China.
Liangxue ZhouDepartment of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, Sichuan, China.
Sichuan University · CNChinese People's Armed Police General Hospital · CNFirst Affiliated Hospital of Chengdu Medical College · CNGuiyang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The secretome secreted by stem cells and bioactive material has emerged as a promising therapeutic choice for traumatic brain injury (TBI). We aimed to determine the effect of 3D-printed collagen/chitosan/secretome derived from human umbilical cord blood mesenchymal stem cells scaffolds (3D-CC-ST) on the injured tissue regeneration process. 3D-CC-ST was performed using 3D printing technology at a low temperature (-20°C), and the physical properties and degeneration rate were measured. The utilization of low temperature contributed to a higher cytocompatibility of fabricating porous 3D architectures that provide a homogeneous distribution of cells. Immediately after the establishment of the canine TBI model, 3D-CC-ST and 3D-CC (3D-printed collagen/chitosan scaffolds) were implanted into the cavity of TBI. Following implantation of scaffolds, neurological examination and motor evoked potential detection were performed to analyze locomotor function recovery. Histological and immunofluorescence staining were performed to evaluate neuro-regeneration. The group treated with 3D-CC-ST had good performance of behavior functions. Implanting 3D-CC-ST significantly reduced the cavity area, facilitated the regeneration of nerve fibers and vessel reconstruction, and promoted endogenous neuronal differentiation and synapse formation after TBI. The implantation of 3D-CC-ST also markedly reduced cell apoptosis and regulated the level of systemic inflammatory factors after TBI.

Indexed as

canineschitosancollagenlow temperature extrusion 3D printingsecretometraumatic brain injury

Identifiers

PMID35855109
PMCPMC9290528
OpenAlexW4283592236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.