Evidence map›Paper›PMID 35854994›Full record

ArticleOpen forum infectious diseases2022

Supratherapeutic Tacrolimus Concentrations With Nirmatrelvir/Ritonavir in Solid Organ Transplant Recipients Requiring Hospitalization: A Case Series Using Rifampin for Reversal.

Dusten T Rose, Saurin M Gandhi, Rachael A Bedard, Kristin E Mondy, Alexander L Chu, Kelly C Gamble, Amanda T Gee, Monica A Kundra, Amber L Williams, Brian K Lee

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Dusten T RoseDepartment of Pharmacy, Ascension Seton, Dell Seton Medical at The University of Texas, Austin, Texas, USA.ORCID https://orcid.org/0000-0002-1710-336X
Saurin M GandhiDepartment of Internal Medicine, Dell Medical School, University of Texas at Austin, Austin, Texas, USA.
Rachael A BedardDepartment of Pharmacy, Ascension Seton, Dell Seton Medical at The University of Texas, Austin, Texas, USA.
Kristin E MondyDivision of Infectious Diseases, Department of Internal Medicine, Dell Medical School, University of Texas at Austin, Austin, Texas, USA.
Alexander L ChuDepartment of Medical Education, Dell Medical School, University of Texas at Austin, Austin, Texas, USA.
Kelly C GambleDepartment of Pharmacy, Ascension Seton, Dell Seton Medical at The University of Texas, Austin, Texas, USA.
Amanda T GeeDepartment of Pharmacy, Ascension Seton, Dell Seton Medical at The University of Texas, Austin, Texas, USA.
Monica A KundraDepartment of Internal Medicine, Dell Medical School, University of Texas at Austin, Austin, Texas, USA.
Amber L WilliamsDepartment of Pharmacy, Ascension Seton, Dell Seton Medical at The University of Texas, Austin, Texas, USA.
Brian K LeeKidney and Pancreas Transplant Program, Dell Seton Medical Center, University of Texas at Austin, Austin, Texas, USA.
Seton Medical Center · USThe University of Texas at Austin · USAustin College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nirmatrelvir/ritonavir was recently granted emergency use authorization for mild to moderate coronavirus disease 2019. Drug-drug interactions between ritonavir and tacrolimus are underappreciated by nontransplant providers. We describe 2 solid organ transplant recipients prescribed nirmatrelvir/ritonavir for outpatient use who developed tacrolimus toxicity requiring hospitalization and were managed with rifampin for toxicity reversal.

Indexed as

COVID-19drug interactionsnirmatrelvir/ritonavirtacrolimus

Identifiers

PMID35854994
PMCPMC9277654
OpenAlexW4280594104

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.