Evidence map›Paper›PMID 35854978›Full record

ArticleJournal of the Endocrine Society2022

Variants of

Elizabeth Paz-Pacheco, Jose B Nevado, Eva Maria C Cutiongco-de la Paz, Gabriel V Jasul, Aimee Yvonne Criselle L Aman, Elizabeth Laurize A Ribaya, Mark David G Francisco, Ma Luz Vicenta V Guanzon, May L Uyking-Naranjo, Ma Cecille S Añonuevo-Cruz and 16 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 3 institutions in 1 country.

Elizabeth Paz-PachecoDivision of Endocrinology, Diabetes and Metabolism, Philippine General Hospital, University of the Philippines Manila, Philippines.ORCID https://orcid.org/0000-0003-0232-890X
Jose B NevadoInstitutes of Human Genetics, National Institutes of Health, University of the Philippines Manila, Philippines.
Eva Maria C Cutiongco-de la PazInstitutes of Human Genetics, National Institutes of Health, University of the Philippines Manila, Philippines.
Gabriel V JasulDivision of Endocrinology, Diabetes and Metabolism, Philippine General Hospital, University of the Philippines Manila, Philippines.
Aimee Yvonne Criselle L AmanInstitutes of Human Genetics, National Institutes of Health, University of the Philippines Manila, Philippines.
Elizabeth Laurize A RibayaInstitutes of Human Genetics, National Institutes of Health, University of the Philippines Manila, Philippines.
Mark David G FranciscoDivision of Endocrinology, Diabetes and Metabolism, Philippine General Hospital, University of the Philippines Manila, Philippines.
Ma Luz Vicenta V GuanzonCorazon Locsin Montelibano Memorial Regional Hospital, Bacolod City, Negros Occidental, Philippines.
May L Uyking-NaranjoSouthern Philippines Medical Center, Davao City, Davao del Sur, Philippines.
Ma Cecille S Añonuevo-CruzDivision of Endocrinology, Diabetes and Metabolism, Philippine General Hospital, University of the Philippines Manila, Philippines.
Maria Patricia Deanna D ManingatDivision of Endocrinology, Diabetes and Metabolism, Philippine General Hospital, University of the Philippines Manila, Philippines.
Cristina V JaringDivision of Endocrinology, Diabetes and Metabolism, Philippine General Hospital, University of the Philippines Manila, Philippines.
Paulette D Nacpil-DominguezDivision of Endocrinology, Diabetes and Metabolism, Philippine General Hospital, University of the Philippines Manila, Philippines.
Aniza B Pala-MohamadDivision of Endocrinology, Diabetes and Metabolism, Philippine General Hospital, University of the Philippines Manila, Philippines.
Abigail U CantoDivision of Endocrinology, Diabetes and Metabolism, Philippine General Hospital, University of the Philippines Manila, Philippines.
John Paul M QuisumbingDivision of Endocrinology, Diabetes and Metabolism, Philippine General Hospital, University of the Philippines Manila, Philippines.
Annabelle Marie M LatDivision of Endocrinology, Diabetes and Metabolism, Philippine General Hospital, University of the Philippines Manila, Philippines.
Diane Carla C BernardoDivision of Endocrinology, Diabetes and Metabolism, Philippine General Hospital, University of the Philippines Manila, Philippines.
Noemie Marie M MansibangDivision of Endocrinology, Diabetes and Metabolism, Philippine General Hospital, University of the Philippines Manila, Philippines.
Karell Jo Angelique C CalpitoInstitutes of Human Genetics, National Institutes of Health, University of the Philippines Manila, Philippines.
Vincent Sean D RibayaInstitutes of Human Genetics, National Institutes of Health, University of the Philippines Manila, Philippines.
Julius Patrick Y FerrerInstitutes of Human Genetics, National Institutes of Health, University of the Philippines Manila, Philippines.
Jessica H BiwangInstitutes of Human Genetics, National Institutes of Health, University of the Philippines Manila, Philippines.
Jodelyn B MelegritoInstitutes of Human Genetics, National Institutes of Health, University of the Philippines Manila, Philippines.
Christian Deo T DeguitInstitutes of Human Genetics, National Institutes of Health, University of the Philippines Manila, Philippines.
Carlos Emmanuel G PanerioInstitutes of Human Genetics, National Institutes of Health, University of the Philippines Manila, Philippines.
Philippine General Hospital · PHUniversity of the Philippines Manila · PHDepartment of Science and Technology · PH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: A study among Filipinos revealed that only 15% of patients with diabetes achieved glycemic control, and poor response to metformin could be one of the possible reasons. Recent studies demonstrate how genetic variations influence response to metformin. Hence, the present study aimed to determine genetic variants associated with poor response to metformin. Methods: Using a candidate variant approach, 195 adult Filipino participants with newly diagnosed type 2 diabetes mellitus (T2DM) were enrolled in a case-control study. Genomic DNA from blood samples were collected. Allelic and genotypic associations of variants with poor response to metformin were determined using exact statistical methods. Results: Several polymorphisms were nominally associated with poor response to metformin ( Conclusion: In Filipinos, a trend for the association for several variants was noted, with further observation that several mechanisms may be involved. The results may serve as pilot data for further validation of candidate variants for T2DM pharmacotherapy.

Indexed as

metformin responsepharmacogeneticsSLC2A10

Identifiers

PMID35854978
PMCPMC9278830
OpenAlexW4286207333

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.