Evidence map›Paper›PMID 35854654›Full record

ArticleGut and liver2023

Real-Time Polymerase Chain Reaction for the Detection of

Jin Hee Noh, Ji Yong Ahn, Jene Choi, Young Soo Park, Hee Kyong Na, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Kee Don Choi, Ho June Song and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Gut and liver, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Prevalence and Variability ofAntibiotics (Basel, Switzerland) · 2025
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. OptimizingGut and liver · 2023
    Review
  12. Article
  13. Efficacy and safety of vonoprazan-amoxicillin dual therapy forTherapeutic advances in gastroenterology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Jin Hee NohDepartments of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID 0000-0001-6720-9528
Ji Yong AhnDepartments of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID 0000-0002-0030-3744
Jene ChoiDepartments of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID 0000-0001-7618-7519
Young Soo ParkDepartments of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID 0000-0001-5389-4245
Hee Kyong NaDepartments of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID 0000-0001-6764-9099
Jeong Hoon LeeDepartments of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID 0000-0002-0778-7585
Kee Wook JungDepartments of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID 0000-0002-3771-3691
Do Hoon KimDepartments of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID 0000-0002-4250-4683
Kee Don ChoiDepartments of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID 0000-0002-2517-4109
Ho June SongDepartments of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID 0000-0001-9255-1464
Gin Hyug LeeDepartments of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID 0000-0003-3776-3928
Hwoon-Yong JungDepartments of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID 0000-0003-1281-5859
Jung Mogg KimDepartment of Microbiology, Hanyang University College of Medicine, Seoul, Korea.ORCID 0000-0002-6506-7519
Ulsan College · KRHanyang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aims: Real-time polymerase chain reaction (RT-PCR) is a fast and simple method for the simultaneous detection of clarithromycin (CLR) resistance and Methods: A total of 70 specimens with confirmed Results: Among the 70 specimens analyzed, the positivity rate was 97.1% (68/70) with RT-PCR and 82.9% (58/70) with RUT. CLR resistance (minimum inhibitory concentration >1.0 μg/mL) was confirmed in 18.6% (13/70), and fluorescence melting curve analysis showed that 84.6% (11/13) had point mutations in 23S rRNA. Ten specimens had only A2143G mutation, and one specimen contained both A2142G and A2143G mutations. Conclusions: RT-PCR assay was found to be more efficient than RUT in detecting

Indexed as

Helicobacter InfectionsHelicobacter pyloriAnti-Bacterial AgentsClarithromycinDrug Resistance, BacterialHumansMicrobial Sensitivity TestsProspective StudiesReal-Time Polymerase Chain ReactionRNA, Ribosomal, 23SAnti-Bacterial AgentsClarithromycinRNA, Ribosomal, 23SClarithromycin resistanceCultureRapid urease testReal-time polymerase chain reaction

Identifiers

PMID35854654
PMCPMC10191795
OpenAlexW4285900301

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.