Evidence map›Paper›PMID 35854329›Full record

ArticleTrials2022

Manual acupuncture as prophylaxis for migraine without aura: study protocol for a multi-center, randomized, single-blinded trial.

Jiao Chen, Siyuan Zhou, Mingsheng Sun, Yanan Wang, Xiaoqin Chen, Taipin Guo, Lu Liu, Jing Luo, Xixiu Ni, Xuguang Yang and 5 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Jiao Chen *Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, No.37 Shier Qiao Road, Chengdu, 610075, Sichuan, China.
Siyuan Zhou *Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, No.37 Shier Qiao Road, Chengdu, 610075, Sichuan, China.
Mingsheng Sun *Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, No.37 Shier Qiao Road, Chengdu, 610075, Sichuan, China.
Yanan WangAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, No.37 Shier Qiao Road, Chengdu, 610075, Sichuan, China.
Xiaoqin ChenChengdu Pidu District Hospital of Traditional Chinese Medicine, No. 342, South Street, Pidu District, Chengdu, 610075, Sichuan, China.
Taipin GuoAcupuncture and Massage-Rehabilitation School, Yunnan University of Chinese Medicine, No.1076 Yuhua Road, Kunming, 650500, Yunnan, China.
Lu LiuAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, No.37 Shier Qiao Road, Chengdu, 610075, Sichuan, China.
Jing LuoHospital (T. C. M) Affiliated to Southwest Medical University, No.182 Chunhui Road, Longmatan District, Luzhou City, 610075, Sichuan, China.
Xixiu NiAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, No.37 Shier Qiao Road, Chengdu, 610075, Sichuan, China.
Xuguang YangThird Affiliated Hospital of Henan University of Traditional Chinese Medicine, No.63, Dongming Road, Zhengzhou, 450000, Henan, China.
Dehua LiAffiliated Hospital of Chengdu University of Traditional Chinese Medicine, No.39 Shier Qiao Road, Chengdu, 610075, Sichuan, China.
Shan GaoAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, No.37 Shier Qiao Road, Chengdu, 610075, Sichuan, China.
Zhenxi HeAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, No.37 Shier Qiao Road, Chengdu, 610075, Sichuan, China.
Dingjun CaiAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, No.37 Shier Qiao Road, Chengdu, 610075, Sichuan, China.
Ling ZhaoAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, No.37 Shier Qiao Road, Chengdu, 610075, Sichuan, China. zhaoling@cdutcm.edu.cn.ORCID http://orcid.org/0000-0002-3955-0072
Chengdu University of Traditional Chinese Medicine · CNHenan University of Traditional Chinese Medicine · CNSouthwest Medical University · CNYunnan University of Traditional Chinese Medicine · CN

Funding

national key research and development project 2019YFC1709700national natural science foundation of china 81973962
6 · The paper itself

Abstract

backgroundMigraine is a highly prevalent neurological disorder. It is the third most prevalent disorder and the seventh highest cause of disability worldwide. Acupuncture may be a viable prophylactic treatment option for frequent or uncontrolled migraine. Clinical studies comparing acupuncture and placebo acupuncture have not reached a consistent conclusion in confirming whether acupuncture is effective in migraine prophylaxis. The effect of acupuncture mainly depends on acupoints and needles operation. We found that the design of the placebo acupuncture in previous studies included shallow needling at sham acupoints, non-penetrating needling at sham acupoints, and needling at inactive acupuncture points to achieve the inert effect of control group, but the non-penetrating needling at true acupoints was ignored. This randomized controlled trial aims to use true acupoints for non-penetrating acupuncture as control to evaluate the efficacy of manual acupuncture for the prophylaxis of migraine without aura (MWoA). METHODS/

designThis is a single-blinded, randomized, controlled, prospective, multi-center trial with two parallel treatment groups. A total of 198 eligible patients with MWoA will be randomly divided into two groups (1:1 allocation ratio). The intervention group will receive manual acupuncture and the control group will receive placebo acupuncture (non-penetrating). Patients will receive three acupuncture treatment sessions per week for 4 consecutive weeks. All patients will then receive a 12-week follow-up. DISCUSSION: In this study, we are evaluating the efficacy and safety of manual acupuncture in the prophylaxis of MWoA. The placebo control is using non-penetrating needling verum acupoints. It is essential to determine an appropriate control method to ensure the methodological quality of a randomized controlled trial.

trial registrationThe trial has been registered in the Chinese Clinical Trial Registry (approval no. ChiCTR2000032308 ) in April 2020.

Indexed as

Acupuncture TherapyMigraine without AuraAcupuncture PointsHumansMulticenter Studies as TopicProspective StudiesRandomized Controlled Trials as TopicTreatment OutcomeClinical trial protocolMigraine without auraRandomized controlled trial

Identifiers

PMID35854329
PMCPMC9295267
OpenAlexW4285798801

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.