Evidence map›Paper›PMID 35854324›Full record

Trial reportBMC psychology2022

Qualitative study of patient experiences of mental distress during TB investigation and treatment in Zambia.

T Mainga, M Gondwe, I Mactaggart, R C Stewart, K Shanaube, H Ayles, V Bond

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC psychology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03739736 (Tuberculosis Reduction Through Expanded Anti-retroviral Therapy and Screening of Active TB Project), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03739736 unknown statusnot on this map

Tuberculosis Reduction Through Expanded Anti-retroviral Therapy and Screening of Active TB Project

TypeobservationalSponsorLondon School of Hygiene and Tropical MedicineRan2018 to 2021Enrolled4,200ConditionsTuberculosis, HIV/AIDSArmsCombination of TB/HIV prevention activities (arm A), Combination of TB/HIV prevention activities (arm B), Standard of care (arm C)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

T MaingaZambart, University of Zambia School of Public Health, Ridgeway, Zambia. Tila.Mainga1@lshtm.ac.uk.ORCID http://orcid.org/0000-0002-7711-3623
M GondweZambart, University of Zambia School of Public Health, Ridgeway, Zambia.
I MactaggartDepartment of Department of Population Health, International Centre for Evidence in Disability, London School of Hygiene and Tropical Medicine, London, UK.
R C StewartDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
K ShanaubeZambart, University of Zambia School of Public Health, Ridgeway, Zambia.
H AylesZambart, University of Zambia School of Public Health, Ridgeway, Zambia.
V BondZambart, University of Zambia School of Public Health, Ridgeway, Zambia.

Funding

Medical Research Council MR/S035818/1
6 · The paper itself

Abstract

backgroundThe mental health and TB syndemic is a topic that remains under-researched with a significant gap in acknowledging and recognizing patient experiences, particularly in the sub-Saharan African region. In this qualitative study conducted in Zambia, we aimed to explore the lived mental health experiences of TB patients focusing on their multi-layered drivers of distress, and by so doing highlighting contextual factors that influence mental distress in TB patients in this setting.

methodsThe study draws on qualitative data collected in 2018 as part of the Tuberculosis Reduction through Expanded Antiretroviral Treatment and Screening for active TB trial (TREATS) being conducted in Zambia. The data was collected through in-depth interviews with former TB patients (n = 80) from 8 urban communities participating in the TREATS trial. Thematic analysis was conducted. Additional quantitative exploratory analysis mapping mental distress symptoms on demographic, social, economic and TB characteristics of participants was conducted.

resultsMost participants (76%) shared that they had experienced some form of mental distress during their TB investigation and treatment period. The reported symptoms ranged in severity. Some participants reported mild distress that did not disrupt their daily lives or ability to adhere to their TB medication, while other participants reported more severe symptoms of distress, for example, 15% of participants shared that they had suicidal ideation and thoughts of self-harm during their time on treatment. Mental distress was driven by unique interactions between individual, social and health level factors most of which were inextricably linked to poverty. Mental distress caused by individual level drivers such as TB morbidity often abated once participants started feeling better, however social, economic and health system level drivers of distress persisted during and beyond TB treatment.

conclusionThe findings illustrate that mental distress during TB is driven by multi-layered and intersecting stresses, with the economic stress of poverty often being the most powerful driver. Measures are urgently needed to support TB patients during the investigation and treatment phase, including increased availability of mental health services, better social security safety nets during TB treatment, and interventions targeting TB, HIV and mental health stigma. Trial registration ClinicalTrials.gov NCT03739736 . Trial registration date: November 14, 2018.

Indexed as

TuberculosisHumansPatient Outcome AssessmentQualitative ResearchSocial StigmaZambiaContextual driversMental distressPatient experiencesPovertyTuberculosisZambia

Identifiers

PMID35854324
PMCPMC9295264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.